Oligomycin toxicity in intact rats

Intraperitoneal injection of oligomycin into the rat (0.5 mg per kg, corresponding to the LD33 dose) reduces the oxygen consumption by about 50%, whereas the arterial pO2 remains normal. The large extent of this decrease points to an involvement of liver and muscle tissue. Triiodothyronine pretreatm...

Full description

Saved in:
Bibliographic Details
Published in:Agents and Actions 1984-12, Vol.15 (5-6), p.660-663
Main Authors: Kramar, R, Hohenegger, M, Srour, A N, Khanakah, G
Format: Article
Language:English
Subjects:
Animals
Hemodynamics - drug effects
Kidney - drug effects
Mitochondria - drug effects
Oligomycins - toxicity
Oxygen Consumption - drug effects
Rats
Rats, Inbred Strains
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Intraperitoneal injection of oligomycin into the rat (0.5 mg per kg, corresponding to the LD33 dose) reduces the oxygen consumption by about 50%, whereas the arterial pO2 remains normal. The large extent of this decrease points to an involvement of liver and muscle tissue. Triiodothyronine pretreatment (3 doses of 0.075 mg/100 g body weight) is not able to prevent this effect. From the blood metabolites measured glucose, pyruvate and the parameters of lipid metabolism remain unchanged; only lactate is significantly increased, causing compensated metabolic acidosis. Heart rate, systolic blood pressure and electrocardiogram are essentially unchanged. Oliguria, reduced renal excretion of urea and increase of plasma urea also indicate a nephrotoxic action. The results are discussed in comparison with some effects of experimental uremia.
ISSN:0065-4299
1420-908X
DOI:10.1007/BF01966788