Induction of collagenase synthesis in chondrocytes by a factor synthesized by inflamed synovial tissue

Rabbit inflamed synovial tissue grown in culture synthesizes a factor that induces collagenase synthesis in chondrocytes and in cartilage. Synthesis of this factor by the synovial tissue is inhibited by cycloheximide but not by indomethacin. The factor has an apparent molecular weight of 30,000, is...

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Bibliographic Details
Published in:Agents and Actions 1984-01, Vol.14 (1), p.54-57
Main Authors: Kerwar, S S, Ridge, S C, Landes, M J, Nolan, J C, Oronsky, A L
Format: Article
Language:English
Subjects:
Animals
Cartilage, Articular - cytology
Cartilage, Articular - enzymology
Enzyme Induction
In Vitro Techniques
Kinetics
Microbial Collagenase - biosynthesis
Protein Biosynthesis
Rabbits
Synovitis - metabolism
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Summary:Rabbit inflamed synovial tissue grown in culture synthesizes a factor that induces collagenase synthesis in chondrocytes and in cartilage. Synthesis of this factor by the synovial tissue is inhibited by cycloheximide but not by indomethacin. The factor has an apparent molecular weight of 30,000, is stable to heat and to trypsin treatment but is inactivated by acid. Induction of collagenase synthesis in chondrocytes occurs after a lag period of 6 hours.
ISSN:0065-4299
1420-908X
DOI:10.1007/BF01966833