Induction of collagenase synthesis in chondrocytes by a factor synthesized by inflamed synovial tissue

Rabbit inflamed synovial tissue grown in culture synthesizes a factor that induces collagenase synthesis in chondrocytes and in cartilage. Synthesis of this factor by the synovial tissue is inhibited by cycloheximide but not by indomethacin. The factor has an apparent molecular weight of 30,000, is...

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Published in:Agents and Actions 1984-01, Vol.14 (1), p.54-57
Main Authors: Kerwar, S S, Ridge, S C, Landes, M J, Nolan, J C, Oronsky, A L
Format: Article
Language:English
Subjects:
Animals
Cartilage, Articular - cytology
Cartilage, Articular - enzymology
Enzyme Induction
In Vitro Techniques
Kinetics
Microbial Collagenase - biosynthesis
Protein Biosynthesis
Rabbits
Synovitis - metabolism
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creator Kerwar, S S
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Landes, M J
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description Rabbit inflamed synovial tissue grown in culture synthesizes a factor that induces collagenase synthesis in chondrocytes and in cartilage. Synthesis of this factor by the synovial tissue is inhibited by cycloheximide but not by indomethacin. The factor has an apparent molecular weight of 30,000, is stable to heat and to trypsin treatment but is inactivated by acid. Induction of collagenase synthesis in chondrocytes occurs after a lag period of 6 hours.
doi_str_mv 10.1007/BF01966833
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subjects Animals
Cartilage, Articular - cytology
Cartilage, Articular - enzymology
Enzyme Induction
In Vitro Techniques
Kinetics
Microbial Collagenase - biosynthesis
Protein Biosynthesis
Rabbits
Synovitis - metabolism
title Induction of collagenase synthesis in chondrocytes by a factor synthesized by inflamed synovial tissue
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