The release of interleukin-1-like activity by macrophages in two models of immunological inflammation in the rat

Interleukin-1 (IL-1) is a putative mediator of inflammation released by activated macrophages in vitro. The IL-1 release by rat macrophages collected either from exudates in pertussis-induced air pouches or from the peritoneum during adjuvant arthritis has been investigated. In air pouch inflammatio...

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Bibliographic Details
Published in:Agents and Actions 1989-11, Vol.28 (3-4), p.243-247
Main Authors: Becherucci, C, Donati, D, Perretti, M, Parente, L
Format: Article
Language:English
Subjects:
Air
Animals
Arthritis, Experimental - metabolism
Biological Assay
Bordetella pertussis - immunology
Cells, Cultured
Disease Models, Animal
Inflammation - immunology
Inflammation - metabolism
Interleukin-1 - metabolism
Macrophages - metabolism
Male
Mice
Mice, Inbred C3H
Rats
Rats, Inbred Lew
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Summary:Interleukin-1 (IL-1) is a putative mediator of inflammation released by activated macrophages in vitro. The IL-1 release by rat macrophages collected either from exudates in pertussis-induced air pouches or from the peritoneum during adjuvant arthritis has been investigated. In air pouch inflammation LPS-stimulated macrophages collected from sensitized animals release more IL-1 than cells from control rats at day 6 after challenge. This enhanced IL-1 release parallels the extent of mononuclear cell migration in the inflammatory lesion. In adjuvant arthritis LPS-stimulated macrophages collected from sensitized animals release more IL-1 than cells from control rats at days 16 and 23 after adjuvant injection. The secondary inflammation in arthritic rats was statistically significant at days 16 to 28. These results indicate that during immunological inflammation macrophages either from the inflamed area or from a non-inflamed region release more IL-1 than control cells. This release parallels the extent of the inflammation and may be important in its pathogenesis.
ISSN:0065-4299
1420-908X
DOI:10.1007/BF01967410