Efficacy of combined ranitidine and pentacaine treatment in experimentally induced gastric damage in rats

Combined treatment with the H2 antagonist ranitidine and the cytoprotective agent pentacaine was studied in acute gastric lesions induced by phenylbutazone and stress, in chronic gastric ulcers induced by acetic acid, and in Shay's model of gastric secretion stimulated by histamine. In all expe...

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Bibliographic Details
Published in:Agents and Actions 1990-04, Vol.30 (1-2), p.185-187
Main Authors: Nosál'ová, V, Babul'ová, A, Benes, L
Format: Article
Language:English
Subjects:
Acetates
Acetic Acid
Anesthetics, Local - administration & dosage
Anesthetics, Local - therapeutic use
Animals
Carbamates - administration & dosage
Carbamates - therapeutic use
Drug Therapy, Combination
Female
Phenylbutazone
Pylorus - physiology
Ranitidine - administration & dosage
Ranitidine - therapeutic use
Rats
Rats, Inbred Strains
Stomach Ulcer - chemically induced
Stomach Ulcer - drug therapy
Stress, Psychological - complications
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Summary:Combined treatment with the H2 antagonist ranitidine and the cytoprotective agent pentacaine was studied in acute gastric lesions induced by phenylbutazone and stress, in chronic gastric ulcers induced by acetic acid, and in Shay's model of gastric secretion stimulated by histamine. In all experimental settings, the effect of the combined treatment was more pronounced than the effect of each drug alone. The resulting antiulcer or antisecretory activity appeared to be additive or, in some cases, synergistic. If confirmed clinically, the combination of ranitidine and pentacaine may prove useful in the treatment of peptic ulcer disease.
ISSN:0065-4299
1420-908X
DOI:10.1007/BF01969033