Histamine metabolism in diabetic rats

Streptozotocin-induced diabetes in rats has been used to study the effect of insulin deficiency on histamine metabolism. There were significant increases in the amine content in the pancreas and intestine, and a significant drop in intestinal diamine oxidase (DAO) activity. The reduced DAO activity...

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Bibliographic Details
Published in:Agents and Actions 1990-04, Vol.30 (1-2), p.243-246
Main Authors: Fogel, W A, Chmielecki, C, Grałek, M, Maslinski, C
Format: Article
Language:English
Subjects:
Amine Oxidase (Copper-Containing) - metabolism
Animals
Blood Glucose - metabolism
Diabetes Mellitus, Experimental - enzymology
Diabetes Mellitus, Experimental - metabolism
Histamine - metabolism
Histamine N-Methyltransferase - metabolism
Insulin - pharmacology
Intestine, Small - enzymology
Intestine, Small - metabolism
Male
Pancreas - enzymology
Pancreas - metabolism
Rats
Rats, Inbred Strains
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Summary:Streptozotocin-induced diabetes in rats has been used to study the effect of insulin deficiency on histamine metabolism. There were significant increases in the amine content in the pancreas and intestine, and a significant drop in intestinal diamine oxidase (DAO) activity. The reduced DAO activity may be of clinical relevance.
ISSN:0065-4299
1420-908X
DOI:10.1007/BF01969050