Vitamin E-induced chronic inflammation in rats

Sub-plantar injection of vitamin E (VE) oil produces a highly localized, chronic inflammation which is sustained for at least 8 weeks. As a result of studies using mediator inhibitors and depletors, it appears that histamine, serotonin, kinins, and prostaglandins may be involved in at least the earl...

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Bibliographic Details
Published in:Agents and Actions 1979-10, Vol.9 (4), p.350-357
Main Authors: Berkenkopf, J W, Lutsky, B N
Format: Article
Language:English
Subjects:
Adrenal Glands - anatomy & histology
Animals
Blood Sedimentation
Cell Membrane - pathology
Chronic Disease
Dose-Response Relationship, Drug
Hematocrit
Inflammation - etiology
Lymph Nodes - anatomy & histology
Male
Organ Size
Rats
Rats, Inbred Lew
Spleen - anatomy & histology
Thymus Gland - anatomy & histology
Vitamin E
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Summary:Sub-plantar injection of vitamin E (VE) oil produces a highly localized, chronic inflammation which is sustained for at least 8 weeks. As a result of studies using mediator inhibitors and depletors, it appears that histamine, serotonin, kinins, and prostaglandins may be involved in at least the early response to VE. This early phase is dominated by a massive influx of neutrophils, with the reaction rapidly progressing to a sustained mononuclear cell pathology. Results of studies in leucopenic rats suggest that edema formation and accumulation of white cells may be dissociable, although at this time it is not possible to conclude that edema can occur in the absence of cells since profoundly leucopenic rats are still able to locally mobilize polymorphonuclear cells in response to VE. Vitamin E-induced inflammation, produced under the conditions described, can be effectively suppressed by corticosteroids but seems relatively insensitive to the action of most non-steroidal anti-inflammatory agents tested.
ISSN:0065-4299
1420-908X
DOI:10.1007/BF01970660