Dose- and sex-independent disposition of ciprofloxacin

Serum concentrations and urinary excretion of ciprofloxacin were studied in female and male volunteers following a single oral administration of 100 mg, 250 mg, 500 mg or 1000 mg. Serum and urine concentrations increased proportionally to the increasing dose administered but independently of sex. Tw...

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Bibliographic Details
Published in:European Journal of Clinical Microbiology 1984-08, Vol.3 (4), p.363-366
Main Authors: Höffler, D, Dalhoff, A, Gau, W, Beermann, D, Michl, A
Format: Article
Language:English
Subjects:
Adult
Anti-Infective Agents - administration & dosage
Anti-Infective Agents - blood
Ciprofloxacin
Dose-Response Relationship, Drug
Female
Humans
Kinetics
Male
Metabolic Clearance Rate
Quinolines - administration & dosage
Quinolines - blood
Sex Factors
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Summary:Serum concentrations and urinary excretion of ciprofloxacin were studied in female and male volunteers following a single oral administration of 100 mg, 250 mg, 500 mg or 1000 mg. Serum and urine concentrations increased proportionally to the increasing dose administered but independently of sex. Twenty-five percent of the administered dose was excreted in the urine as unmetabolized ciprofloxacin within the first 24 hours after oral administration. Renal clearance averaged 5 ml/min X kg.
ISSN:0722-2211
1435-4373
DOI:10.1007/BF01977496