The effect of long-term prostacyclin treatment on the protein, DNA and RNA content of rat gastric fundic mucosa

The changes of gastric fundic mucosal protein, DNA and RNA content have been investigated during long-term (40 and 80 days respectively), prostacyclin treatment. It seems that a longer prostacyclin treatment induces a significant thickening of the gastric fundic mucosa. This phenomenon might be expl...

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Bibliographic Details
Published in:Agents and Actions 1985-07, Vol.16 (5), p.404-406
Main Authors: Balint, G A, Karácsony, G, Varró, V
Format: Article
Language:English
Subjects:
Animals
DNA - metabolism
Epoprostenol - pharmacology
Female
Gastric Fundus
Gastric Mucosa - drug effects
Gastric Mucosa - metabolism
Indomethacin
Proteins - metabolism
Rats
Rats, Inbred Strains
RNA - metabolism
Stomach Ulcer - etiology
Stomach Ulcer - metabolism
Stress, Physiological - complications
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Summary:The changes of gastric fundic mucosal protein, DNA and RNA content have been investigated during long-term (40 and 80 days respectively), prostacyclin treatment. It seems that a longer prostacyclin treatment induces a significant thickening of the gastric fundic mucosa. This phenomenon might be explained by the hyperplasia of matured cells. This assumption is strengthened by the results obtained checking the DNA and RNA-levels of the mucosa.
ISSN:0065-4299
1420-908X
DOI:10.1007/BF01982880