Bronchial hyper-reactivity in atopic patients during H2-receptor blocker treatment

Bronchial reactivity after Cimetidine treatment was evaluated by the histamine provocation test in 24 patients with atopic bronchial asthma and 10 patients with peptic ulcer. Anti-IgE induced histamine release from isolated basophils was also investigated. After blockade of H2 receptors, an increase...

Full description

Saved in:
Bibliographic Details
Published in:Agents and Actions 1986-04, Vol.18 (1-2), p.239-241
Main Authors: Hofman, J, Siergiejko, Z, Bortkiewicz, J, Rutkowski, R, Chyrek-Borowska, S
Format: Article
Language:English
Subjects:
Asthma - physiopathology
Bronchi - drug effects
Bronchi - physiopathology
Bronchial Provocation Tests
Cimetidine - pharmacology
Histamine - pharmacology
Histamine H2 Antagonists - pharmacology
Histamine Release - drug effects
Humans
Peptic Ulcer - physiopathology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Bronchial reactivity after Cimetidine treatment was evaluated by the histamine provocation test in 24 patients with atopic bronchial asthma and 10 patients with peptic ulcer. Anti-IgE induced histamine release from isolated basophils was also investigated. After blockade of H2 receptors, an increase of bronchial reactivity and an exacerbation of clinical symptoms were observed in 4 asthmatic patients [17%]. A moderate increase in bronchial reactivity without exacerbation of asthma symptoms was observed in 16 other patients [66%]. In some of the patients treated with Cimetidine an enhancement of IgE-induced histamine release from isolated basophils was observed.
ISSN:0065-4299
1420-908X
DOI:10.1007/BF01988030