Comparison of the ulcerogenic properties of tepoxalin with those of non-steroidal anti-inflammatory drugs (NSAIDs)

The ability of tepoxalin to render the gastric mucosa susceptible to injury by a topically applied irritant was compared to that of indomethacin, naproxen and diclofenac. While the three NSAIDs significantly increased the extent of mucosal damage at doses in the 1-30 mg/kg range, tepoxalin failed to...

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Bibliographic Details
Published in:Agents and Actions 1991-09, Vol.34 (1-2), p.247-250
Main Authors: Wallace, J L, Cirino, G, Cicala, C, Anderson, D W, Argentieri, D, Capetola, R J
Format: Article
Language:English
Subjects:
Animals
Anti-Inflammatory Agents, Non-Steroidal - toxicity
Gastric Mucosa - drug effects
Male
Pyrazoles - toxicity
Rats
Rats, Inbred Strains
Species Specificity
Stomach Ulcer - chemically induced
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Summary:The ability of tepoxalin to render the gastric mucosa susceptible to injury by a topically applied irritant was compared to that of indomethacin, naproxen and diclofenac. While the three NSAIDs significantly increased the extent of mucosal damage at doses in the 1-30 mg/kg range, tepoxalin failed to significantly augment damage at doses of up to 300 mg/kg. Daily treatment with tepoxalin (10-100 mg/kg) for 4 days also did not significantly affect the susceptibility of the gastric mucosa to damage. The absence of ulcerogenic properties of tepoxalin at doses previously shown to be anti-inflammatory may be related to its relative lack of activity as an inhibitor of gastric prostaglandin synthesis, or to its 5-lipoxygenase inhibitory activity.
ISSN:0065-4299
1420-908X
DOI:10.1007/BF01993294