Evaluation of potential practical oral contrast agents for pediatric magnetic resonance imaging: preliminary observations

Development of a practical oral contrast agent for magnetic resonance imaging is necessary to improve differentiation of bowel from adjacent structures. In order to find a readily available, inexpensive, non-toxic, palatable solution for use in the pediatric population, several formulas, milk produc...

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Bibliographic Details
Published in:Pediatric radiology 1989-11, Vol.20 (1-2), p.61-66
Main Author: BISSET, G. S. III
Format: Article
Language:English
Subjects:
Administration, Oral
Adolescent
Adult
Biological and medical sciences
Child
Colon - pathology
Contrast Media - administration & dosage
Digestive system
Duodenum - pathology
Humans
Image Enhancement - methods
Intestine, Small - pathology
Investigative techniques, diagnostic techniques (general aspects)
Magnetic Resonance Imaging - methods
Medical sciences
Radiodiagnosis. Nmr imagery. Nmr spectrometry
Stomach - pathology
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Summary:Development of a practical oral contrast agent for magnetic resonance imaging is necessary to improve differentiation of bowel from adjacent structures. In order to find a readily available, inexpensive, non-toxic, palatable solution for use in the pediatric population, several formulas, milk products and a common oral sedative were evaluated in vitro. T1, T2 and signal intensity measurements were performed on a 1.5 T system. Similac with standard iron proved to be a useful high signal intensity agent on multiple pulse sequences. Early in vivo experience in four normal volunteers indicates that this agent provides excellent delineation of the stomach and duodenum from contiguous viscera. Distal small bowel visualization is less predictable. Further clinical trials should confirm the utility of this solution, which contains a combination of iron salts and paramagnetic metallic ions.
ISSN:0301-0449
1432-1998
DOI:10.1007/BF02010636