Lectin-mediated bacterial adhesion to human tissue

In vitro experiments with frozen sections of human lung and kidney demonstrated that adhesion of Streptococcus pneumoniae Pn 629 Type 14 and Pseudomonas aeruginosa ATCC 27853 to human cells was mediated by bacterial lectins (adhesins) with N-acetyl-D-glucosamine/D-galactose or N-acetyl-neuraminic ac...

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Bibliographic Details
Published in:European Journal of Clinical Microbiology 1987-10, Vol.6 (5), p.591-593
Main Authors: Beuth, J, Ko, H L, Uhlenbruck, G, Pulverer, G
Format: Article
Language:English
Subjects:
Acetylglucosamine - pharmacology
Adhesins, Bacterial
Bacterial Adhesion
Bacterial Proteins - metabolism
Humans
Kidney - microbiology
Lectins - metabolism
Lung - microbiology
Pseudomonas aeruginosa - physiology
Sialic Acids - pharmacology
Streptococcus pneumoniae - physiology
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Summary:In vitro experiments with frozen sections of human lung and kidney demonstrated that adhesion of Streptococcus pneumoniae Pn 629 Type 14 and Pseudomonas aeruginosa ATCC 27853 to human cells was mediated by bacterial lectins (adhesins) with N-acetyl-D-glucosamine/D-galactose or N-acetyl-neuraminic acid specificity. Blocking of the lectin binding sites on bacterial surfaces with competitive carbohydrates completely prevented the bacterial adherence, whereas non-specific carbohydrates (D-mannose, D-xylose) did not inhibit adherence.
ISSN:0722-2211
1435-4373
DOI:10.1007/BF02014258