Phosphopyridoxal complexes with histamine and histidine. (1) The kinetics of complex formation between pyridoxal 5'-phosphate and histamine

Amines and amino acids are able to form cyclic compounds with pyridoxal 5'-phosphate (PLP). The quantitative relationship between histamine and PLP in the cyclization reaction were examined. It was found that one mole of amine reacts with one mole of coenzyme. The velocity of complex formation...

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Bibliographic Details
Published in:Agents and Actions 1975-02, Vol.5 (1), p.15-19
Main Authors: Kierska, D, Sasiak, K, Boguslawski, M, Maśliński, C
Format: Article
Language:English
Subjects:
Chemical Phenomena
Chemistry
Chromatography, Paper
Cyclization
Histamine - isolation & purification
Histidine - isolation & purification
Kinetics
Osmolar Concentration
Pyridoxal Phosphate - isolation & purification
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Summary:Amines and amino acids are able to form cyclic compounds with pyridoxal 5'-phosphate (PLP). The quantitative relationship between histamine and PLP in the cyclization reaction were examined. It was found that one mole of amine reacts with one mole of coenzyme. The velocity of complex formation increased with an excess of either histamine or PLP, without any change in molar ratios. The formation of cyclic compound was confirmed by the use of isotopic method. The separation of cyclic compound from histamine, but not from PLP, was achieved by paper chromatography.
ISSN:0065-4299
1420-908X
DOI:10.1007/BF02027152