Loading…
Aging : increased responsiveness of colorectal mucosa to carcinogen stimulation and protective role of folic acid
Recent investigations have demonstrated a protective role for folic acid in dysplasia and neoplasia, through an unknown mechanism. The current study was designed to evaluate whether the protective role of folic acid is due, in part, to its antiproliferative properties. In addition, because colorecta...
Saved in:
| Published in: | Digestive diseases and sciences 1995-02, Vol.40 (2), p.396-401 |
|---|---|
| Main Authors: | , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | |
|---|---|
| cites | cdi_FETCH-LOGICAL-c365t-90538a55c49469ed17ef249f308806b8f98c8eb6c18887df83015d220c90a62d3 |
| container_end_page | 401 |
| container_issue | 2 |
| container_start_page | 396 |
| container_title | Digestive diseases and sciences |
| container_volume | 40 |
| creator | NENSEY, Y. M ARLOW, F. L MAJUMDAR, A. P. N |
| description | Recent investigations have demonstrated a protective role for folic acid in dysplasia and neoplasia, through an unknown mechanism. The current study was designed to evaluate whether the protective role of folic acid is due, in part, to its antiproliferative properties. In addition, because colorectal neoplasia is more common with increasing age, we have compared results in both old (22 months) and young (3 months) rats. Colorectal mucosal explants of rats treated with the known carcinogen methylazoxymethanol, were supplemented with folic acid. Ornithine decarboxylase was then measured as an index of cellular proliferative activity. We observed that supplemental folic acid suppressed carcinogen-induced ornithine decarboxylase activity by 64% in the old and 74% in the young rats. Furthermore, a similar phenomenon was observed for tyrosine kinase, which was measured for comparison. The suppression of hyperproliferative activity by supplemental folic acid may contribute to the protective effect of folic acid in colorectal neoplasia. |
| doi_str_mv | 10.1007/bf02065427 |
| format | article |
| fullrecord | <record><control><sourceid>pubmed_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1007_BF02065427</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>7851205</sourcerecordid><originalsourceid>FETCH-LOGICAL-c365t-90538a55c49469ed17ef249f308806b8f98c8eb6c18887df83015d220c90a62d3</originalsourceid><addsrcrecordid>eNo9kEtLAzEURoMotVY37oUsXAmjN5nJY9zVYlUouNH1kMmjRGaSmkwF_71TWru6F77DWRyErgncEwDx0DqgwFlFxQmaEibKgjIuT9EUCB9_Qvg5usj5CwBqQfgETYRkhAKbou_52oc1fsQ-6GRVtgYnmzcxZP9jg80ZR4d17GKyelAd7rc6ZoWHiLVK2oe4tgHnwffbTg0-BqyCwZsUhxEfDTjFzu4ULnZeY6W9uURnTnXZXh3uDH0unz8Wr8Xq_eVtMV8VuuRsKGpgpVSM6aqueG0NEdbRqnYlSAm8la6WWtqWayKlFMbJEggzlIKuQXFqyhm623t1ijkn65pN8r1Kvw2BZpeteVr-Zxvhmz282ba9NUf00Gncbw-7ylp1LqmgfT5iJa8EIbL8A2_GdSY</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Aging : increased responsiveness of colorectal mucosa to carcinogen stimulation and protective role of folic acid</title><source>Springer Nature - Connect here FIRST to enable access</source><creator>NENSEY, Y. M ; ARLOW, F. L ; MAJUMDAR, A. P. N</creator><creatorcontrib>NENSEY, Y. M ; ARLOW, F. L ; MAJUMDAR, A. P. N</creatorcontrib><description>Recent investigations have demonstrated a protective role for folic acid in dysplasia and neoplasia, through an unknown mechanism. The current study was designed to evaluate whether the protective role of folic acid is due, in part, to its antiproliferative properties. In addition, because colorectal neoplasia is more common with increasing age, we have compared results in both old (22 months) and young (3 months) rats. Colorectal mucosal explants of rats treated with the known carcinogen methylazoxymethanol, were supplemented with folic acid. Ornithine decarboxylase was then measured as an index of cellular proliferative activity. We observed that supplemental folic acid suppressed carcinogen-induced ornithine decarboxylase activity by 64% in the old and 74% in the young rats. Furthermore, a similar phenomenon was observed for tyrosine kinase, which was measured for comparison. The suppression of hyperproliferative activity by supplemental folic acid may contribute to the protective effect of folic acid in colorectal neoplasia.</description><identifier>ISSN: 0163-2116</identifier><identifier>EISSN: 1573-2568</identifier><identifier>DOI: 10.1007/bf02065427</identifier><identifier>PMID: 7851205</identifier><identifier>CODEN: DDSCDJ</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Aging - drug effects ; Aging - metabolism ; Analysis of Variance ; Animals ; Biological and medical sciences ; Carcinogenesis, carcinogens and anticarcinogens ; Colon - chemistry ; Colon - drug effects ; Colon - enzymology ; Folic Acid - pharmacology ; Foods and miscellaneous ; Intestinal Mucosa - chemistry ; Intestinal Mucosa - drug effects ; Intestinal Mucosa - enzymology ; Male ; Medical sciences ; Methylazoxymethanol Acetate - pharmacology ; Organ Culture Techniques ; Ornithine Decarboxylase - analysis ; Ornithine Decarboxylase - drug effects ; Pilot Projects ; Protein-Tyrosine Kinases - analysis ; Protein-Tyrosine Kinases - drug effects ; Rats ; Rats, Inbred F344 ; Rectum - chemistry ; Rectum - drug effects ; Rectum - enzymology ; Specific Pathogen-Free Organisms ; Tumors</subject><ispartof>Digestive diseases and sciences, 1995-02, Vol.40 (2), p.396-401</ispartof><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c365t-90538a55c49469ed17ef249f308806b8f98c8eb6c18887df83015d220c90a62d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3647118$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7851205$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>NENSEY, Y. M</creatorcontrib><creatorcontrib>ARLOW, F. L</creatorcontrib><creatorcontrib>MAJUMDAR, A. P. N</creatorcontrib><title>Aging : increased responsiveness of colorectal mucosa to carcinogen stimulation and protective role of folic acid</title><title>Digestive diseases and sciences</title><addtitle>Dig Dis Sci</addtitle><description>Recent investigations have demonstrated a protective role for folic acid in dysplasia and neoplasia, through an unknown mechanism. The current study was designed to evaluate whether the protective role of folic acid is due, in part, to its antiproliferative properties. In addition, because colorectal neoplasia is more common with increasing age, we have compared results in both old (22 months) and young (3 months) rats. Colorectal mucosal explants of rats treated with the known carcinogen methylazoxymethanol, were supplemented with folic acid. Ornithine decarboxylase was then measured as an index of cellular proliferative activity. We observed that supplemental folic acid suppressed carcinogen-induced ornithine decarboxylase activity by 64% in the old and 74% in the young rats. Furthermore, a similar phenomenon was observed for tyrosine kinase, which was measured for comparison. The suppression of hyperproliferative activity by supplemental folic acid may contribute to the protective effect of folic acid in colorectal neoplasia.</description><subject>Aging - drug effects</subject><subject>Aging - metabolism</subject><subject>Analysis of Variance</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Carcinogenesis, carcinogens and anticarcinogens</subject><subject>Colon - chemistry</subject><subject>Colon - drug effects</subject><subject>Colon - enzymology</subject><subject>Folic Acid - pharmacology</subject><subject>Foods and miscellaneous</subject><subject>Intestinal Mucosa - chemistry</subject><subject>Intestinal Mucosa - drug effects</subject><subject>Intestinal Mucosa - enzymology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Methylazoxymethanol Acetate - pharmacology</subject><subject>Organ Culture Techniques</subject><subject>Ornithine Decarboxylase - analysis</subject><subject>Ornithine Decarboxylase - drug effects</subject><subject>Pilot Projects</subject><subject>Protein-Tyrosine Kinases - analysis</subject><subject>Protein-Tyrosine Kinases - drug effects</subject><subject>Rats</subject><subject>Rats, Inbred F344</subject><subject>Rectum - chemistry</subject><subject>Rectum - drug effects</subject><subject>Rectum - enzymology</subject><subject>Specific Pathogen-Free Organisms</subject><subject>Tumors</subject><issn>0163-2116</issn><issn>1573-2568</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><recordid>eNo9kEtLAzEURoMotVY37oUsXAmjN5nJY9zVYlUouNH1kMmjRGaSmkwF_71TWru6F77DWRyErgncEwDx0DqgwFlFxQmaEibKgjIuT9EUCB9_Qvg5usj5CwBqQfgETYRkhAKbou_52oc1fsQ-6GRVtgYnmzcxZP9jg80ZR4d17GKyelAd7rc6ZoWHiLVK2oe4tgHnwffbTg0-BqyCwZsUhxEfDTjFzu4ULnZeY6W9uURnTnXZXh3uDH0unz8Wr8Xq_eVtMV8VuuRsKGpgpVSM6aqueG0NEdbRqnYlSAm8la6WWtqWayKlFMbJEggzlIKuQXFqyhm623t1ijkn65pN8r1Kvw2BZpeteVr-Zxvhmz282ba9NUf00Gncbw-7ylp1LqmgfT5iJa8EIbL8A2_GdSY</recordid><startdate>19950201</startdate><enddate>19950201</enddate><creator>NENSEY, Y. M</creator><creator>ARLOW, F. L</creator><creator>MAJUMDAR, A. P. N</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19950201</creationdate><title>Aging : increased responsiveness of colorectal mucosa to carcinogen stimulation and protective role of folic acid</title><author>NENSEY, Y. M ; ARLOW, F. L ; MAJUMDAR, A. P. N</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c365t-90538a55c49469ed17ef249f308806b8f98c8eb6c18887df83015d220c90a62d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Aging - drug effects</topic><topic>Aging - metabolism</topic><topic>Analysis of Variance</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Carcinogenesis, carcinogens and anticarcinogens</topic><topic>Colon - chemistry</topic><topic>Colon - drug effects</topic><topic>Colon - enzymology</topic><topic>Folic Acid - pharmacology</topic><topic>Foods and miscellaneous</topic><topic>Intestinal Mucosa - chemistry</topic><topic>Intestinal Mucosa - drug effects</topic><topic>Intestinal Mucosa - enzymology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Methylazoxymethanol Acetate - pharmacology</topic><topic>Organ Culture Techniques</topic><topic>Ornithine Decarboxylase - analysis</topic><topic>Ornithine Decarboxylase - drug effects</topic><topic>Pilot Projects</topic><topic>Protein-Tyrosine Kinases - analysis</topic><topic>Protein-Tyrosine Kinases - drug effects</topic><topic>Rats</topic><topic>Rats, Inbred F344</topic><topic>Rectum - chemistry</topic><topic>Rectum - drug effects</topic><topic>Rectum - enzymology</topic><topic>Specific Pathogen-Free Organisms</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>NENSEY, Y. M</creatorcontrib><creatorcontrib>ARLOW, F. L</creatorcontrib><creatorcontrib>MAJUMDAR, A. P. N</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Digestive diseases and sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>NENSEY, Y. M</au><au>ARLOW, F. L</au><au>MAJUMDAR, A. P. N</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Aging : increased responsiveness of colorectal mucosa to carcinogen stimulation and protective role of folic acid</atitle><jtitle>Digestive diseases and sciences</jtitle><addtitle>Dig Dis Sci</addtitle><date>1995-02-01</date><risdate>1995</risdate><volume>40</volume><issue>2</issue><spage>396</spage><epage>401</epage><pages>396-401</pages><issn>0163-2116</issn><eissn>1573-2568</eissn><coden>DDSCDJ</coden><abstract>Recent investigations have demonstrated a protective role for folic acid in dysplasia and neoplasia, through an unknown mechanism. The current study was designed to evaluate whether the protective role of folic acid is due, in part, to its antiproliferative properties. In addition, because colorectal neoplasia is more common with increasing age, we have compared results in both old (22 months) and young (3 months) rats. Colorectal mucosal explants of rats treated with the known carcinogen methylazoxymethanol, were supplemented with folic acid. Ornithine decarboxylase was then measured as an index of cellular proliferative activity. We observed that supplemental folic acid suppressed carcinogen-induced ornithine decarboxylase activity by 64% in the old and 74% in the young rats. Furthermore, a similar phenomenon was observed for tyrosine kinase, which was measured for comparison. The suppression of hyperproliferative activity by supplemental folic acid may contribute to the protective effect of folic acid in colorectal neoplasia.</abstract><cop>Heidelberg</cop><pub>Springer</pub><pmid>7851205</pmid><doi>10.1007/bf02065427</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0163-2116 |
| ispartof | Digestive diseases and sciences, 1995-02, Vol.40 (2), p.396-401 |
| issn | 0163-2116 1573-2568 |
| language | eng |
| recordid | cdi_crossref_primary_10_1007_BF02065427 |
| source | Springer Nature - Connect here FIRST to enable access |
| subjects | Aging - drug effects Aging - metabolism Analysis of Variance Animals Biological and medical sciences Carcinogenesis, carcinogens and anticarcinogens Colon - chemistry Colon - drug effects Colon - enzymology Folic Acid - pharmacology Foods and miscellaneous Intestinal Mucosa - chemistry Intestinal Mucosa - drug effects Intestinal Mucosa - enzymology Male Medical sciences Methylazoxymethanol Acetate - pharmacology Organ Culture Techniques Ornithine Decarboxylase - analysis Ornithine Decarboxylase - drug effects Pilot Projects Protein-Tyrosine Kinases - analysis Protein-Tyrosine Kinases - drug effects Rats Rats, Inbred F344 Rectum - chemistry Rectum - drug effects Rectum - enzymology Specific Pathogen-Free Organisms Tumors |
| title | Aging : increased responsiveness of colorectal mucosa to carcinogen stimulation and protective role of folic acid |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-02T17%3A31%3A01IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Aging%20:%20increased%20responsiveness%20of%20colorectal%20mucosa%20to%20carcinogen%20stimulation%20and%20protective%20role%20of%20folic%20acid&rft.jtitle=Digestive%20diseases%20and%20sciences&rft.au=NENSEY,%20Y.%20M&rft.date=1995-02-01&rft.volume=40&rft.issue=2&rft.spage=396&rft.epage=401&rft.pages=396-401&rft.issn=0163-2116&rft.eissn=1573-2568&rft.coden=DDSCDJ&rft_id=info:doi/10.1007/bf02065427&rft_dat=%3Cpubmed_cross%3E7851205%3C/pubmed_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c365t-90538a55c49469ed17ef249f308806b8f98c8eb6c18887df83015d220c90a62d3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_id=info:pmid/7851205&rfr_iscdi=true |