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Cellular cytotoxicity against autologous hepatocytes in children with different forms of chronic hepatitis B
Cell-mediated immune reactions play the most important role in the pathogenesis of chronic viral and auto-immune hepatitis. Cellular cytotoxicity (CC) of peripheral blood lymphocytes against autologous hepatocytes isolated from liver biopsies was studied in 29 children with different types of hepati...
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| Published in: | European journal of pediatrics 1990-09, Vol.149 (12), p.829-832 |
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| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c241t-c10ef2b3ddbc1162a4d638f0a3a61b0b091fe1d6346391b2264dc37939662e463 |
| container_end_page | 832 |
| container_issue | 12 |
| container_start_page | 829 |
| container_title | European journal of pediatrics |
| container_volume | 149 |
| creator | Keller, K M Poralla, T Dienes, H P Wirth, S Baumann, W |
| description | Cell-mediated immune reactions play the most important role in the pathogenesis of chronic viral and auto-immune hepatitis. Cellular cytotoxicity (CC) of peripheral blood lymphocytes against autologous hepatocytes isolated from liver biopsies was studied in 29 children with different types of hepatitis B surface antigen (HBsAg)-positive hepatitis. Children with chronic hepatitis B showed higher cytotoxicity than control patients. However, a correlation of cytotoxicity to serum amino-transferases, HBeAg-/Anti-HBe-status, and hepatitis B virus DNA in serum could not be found. Children with a higher percentage of hepatitis B core antigen (HBcAg) expression in their liver tissue presented lower CC values, and vice versa. This supports the hypothesis that virus elimination occurs via T-cell attack against HBcAg expressing hepatocytes. Furthermore, children with a longer duration of chronic hepatitis B had considerably higher cytotoxicity values. Possibly, CC plays a role in perpetuating liver damage after infection with hepatitis B virus. |
| doi_str_mv | 10.1007/BF02072068 |
| format | article |
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Cellular cytotoxicity (CC) of peripheral blood lymphocytes against autologous hepatocytes isolated from liver biopsies was studied in 29 children with different types of hepatitis B surface antigen (HBsAg)-positive hepatitis. Children with chronic hepatitis B showed higher cytotoxicity than control patients. However, a correlation of cytotoxicity to serum amino-transferases, HBeAg-/Anti-HBe-status, and hepatitis B virus DNA in serum could not be found. Children with a higher percentage of hepatitis B core antigen (HBcAg) expression in their liver tissue presented lower CC values, and vice versa. This supports the hypothesis that virus elimination occurs via T-cell attack against HBcAg expressing hepatocytes. Furthermore, children with a longer duration of chronic hepatitis B had considerably higher cytotoxicity values. 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Cellular cytotoxicity (CC) of peripheral blood lymphocytes against autologous hepatocytes isolated from liver biopsies was studied in 29 children with different types of hepatitis B surface antigen (HBsAg)-positive hepatitis. Children with chronic hepatitis B showed higher cytotoxicity than control patients. However, a correlation of cytotoxicity to serum amino-transferases, HBeAg-/Anti-HBe-status, and hepatitis B virus DNA in serum could not be found. Children with a higher percentage of hepatitis B core antigen (HBcAg) expression in their liver tissue presented lower CC values, and vice versa. This supports the hypothesis that virus elimination occurs via T-cell attack against HBcAg expressing hepatocytes. Furthermore, children with a longer duration of chronic hepatitis B had considerably higher cytotoxicity values. Possibly, CC plays a role in perpetuating liver damage after infection with hepatitis B virus.</description><subject>Adolescent</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Cytotoxicity Tests, Immunologic</subject><subject>Cytotoxicity, Immunologic</subject><subject>DNA, Viral - isolation & purification</subject><subject>Female</subject><subject>Hepatitis B - immunology</subject><subject>Hepatitis B Core Antigens - isolation & purification</subject><subject>Hepatitis B e Antigens - isolation & purification</subject><subject>Hepatitis, Chronic - immunology</subject><subject>Humans</subject><subject>Infant</subject><subject>Liver - cytology</subject><subject>Liver - immunology</subject><subject>Male</subject><subject>Transaminases - blood</subject><issn>0340-6199</issn><issn>1432-1076</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><recordid>eNpFkEFLAzEQRoMotVYv3oWchdWZZM12j3axKhS86HnJZpM2km5KkkX774206GmYj_cNzCPkGuEOAar7xRIYVAzE_IRMseSsQKjEKZkCL6EQWNfn5CLGT8hwjfMJmTDGxIOopsQ12rnRyUDVPvnkv62yaU_lWtohJirH5J1f-zHSjd7J5DOlI7UDVRvr-qAH-mXThvbWGJ23RI0P20i9yUDwg1WHnk020sUlOTPSRX11nDPysXx6b16K1dvza_O4KhQrMRUKQRvW8b7vFKJgsuwFnxuQXArsoIMajcaclYLX2OVXyl7xqua1EEzncEZuD3dV8DEGbdpdsFsZ9i1C-2us_TeW4ZsDvBu7re7_0KMi_gPoGGeT</recordid><startdate>199009</startdate><enddate>199009</enddate><creator>Keller, K M</creator><creator>Poralla, T</creator><creator>Dienes, H P</creator><creator>Wirth, S</creator><creator>Baumann, W</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>199009</creationdate><title>Cellular cytotoxicity against autologous hepatocytes in children with different forms of chronic hepatitis B</title><author>Keller, K M ; Poralla, T ; Dienes, H P ; Wirth, S ; Baumann, W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c241t-c10ef2b3ddbc1162a4d638f0a3a61b0b091fe1d6346391b2264dc37939662e463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Adolescent</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Cytotoxicity Tests, Immunologic</topic><topic>Cytotoxicity, Immunologic</topic><topic>DNA, Viral - isolation & purification</topic><topic>Female</topic><topic>Hepatitis B - immunology</topic><topic>Hepatitis B Core Antigens - isolation & purification</topic><topic>Hepatitis B e Antigens - isolation & purification</topic><topic>Hepatitis, Chronic - immunology</topic><topic>Humans</topic><topic>Infant</topic><topic>Liver - cytology</topic><topic>Liver - immunology</topic><topic>Male</topic><topic>Transaminases - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Keller, K M</creatorcontrib><creatorcontrib>Poralla, T</creatorcontrib><creatorcontrib>Dienes, H P</creatorcontrib><creatorcontrib>Wirth, S</creatorcontrib><creatorcontrib>Baumann, W</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>European journal of pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Keller, K M</au><au>Poralla, T</au><au>Dienes, H P</au><au>Wirth, S</au><au>Baumann, W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cellular cytotoxicity against autologous hepatocytes in children with different forms of chronic hepatitis B</atitle><jtitle>European journal of pediatrics</jtitle><addtitle>Eur J Pediatr</addtitle><date>1990-09</date><risdate>1990</risdate><volume>149</volume><issue>12</issue><spage>829</spage><epage>832</epage><pages>829-832</pages><issn>0340-6199</issn><eissn>1432-1076</eissn><abstract>Cell-mediated immune reactions play the most important role in the pathogenesis of chronic viral and auto-immune hepatitis. Cellular cytotoxicity (CC) of peripheral blood lymphocytes against autologous hepatocytes isolated from liver biopsies was studied in 29 children with different types of hepatitis B surface antigen (HBsAg)-positive hepatitis. Children with chronic hepatitis B showed higher cytotoxicity than control patients. However, a correlation of cytotoxicity to serum amino-transferases, HBeAg-/Anti-HBe-status, and hepatitis B virus DNA in serum could not be found. Children with a higher percentage of hepatitis B core antigen (HBcAg) expression in their liver tissue presented lower CC values, and vice versa. This supports the hypothesis that virus elimination occurs via T-cell attack against HBcAg expressing hepatocytes. Furthermore, children with a longer duration of chronic hepatitis B had considerably higher cytotoxicity values. Possibly, CC plays a role in perpetuating liver damage after infection with hepatitis B virus.</abstract><cop>Germany</cop><pmid>2226567</pmid><doi>10.1007/BF02072068</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0340-6199 |
| ispartof | European journal of pediatrics, 1990-09, Vol.149 (12), p.829-832 |
| issn | 0340-6199 1432-1076 |
| language | eng |
| recordid | cdi_crossref_primary_10_1007_BF02072068 |
| source | Springer LINK Archives |
| subjects | Adolescent Child Child, Preschool Cytotoxicity Tests, Immunologic Cytotoxicity, Immunologic DNA, Viral - isolation & purification Female Hepatitis B - immunology Hepatitis B Core Antigens - isolation & purification Hepatitis B e Antigens - isolation & purification Hepatitis, Chronic - immunology Humans Infant Liver - cytology Liver - immunology Male Transaminases - blood |
| title | Cellular cytotoxicity against autologous hepatocytes in children with different forms of chronic hepatitis B |
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