Membrane sialic acid influences basophil histamine release by interfering with calcium dependence

The influence of the cell membrane content of sialic acid on basophil histamine release was examined in vitro in allergic patients and normal controls. Enzymatical removal of sialic acid enhanced histamine release induced by allergen and anti-IgE, whereas an increase in membrane sialic acid content...

Full description

Saved in:
Bibliographic Details
Published in:Agents and Actions 1987-04, Vol.20 (3-4), p.161-164
Main Authors: Jensen, C, Norn, S, Skov, P S, Dahl, B T, Thastrup, O, Leon, A, Svendsen, U G
Format: Article
Language:English
Subjects:
Basophils - drug effects
Basophils - physiology
Calcium - physiology
Calcium Channel Blockers - pharmacology
Cell Membrane - physiology
Histamine Release - drug effects
Humans
In Vitro Techniques
Ion Channels - physiology
Rhinitis, Allergic, Seasonal - blood
Sialic Acids - physiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The influence of the cell membrane content of sialic acid on basophil histamine release was examined in vitro in allergic patients and normal controls. Enzymatical removal of sialic acid enhanced histamine release induced by allergen and anti-IgE, whereas an increase in membrane sialic acid content by insertion of sialic acid containing gangliosides into the membrane inhibited the mediator release. The reduction in membrane sialic acid content abolished the inhibitory capacity of the calcium channel antagonist nimodipine, whereas the inhibition produced by verapamil and lanthanum was not affected. This difference, together with the previous finding that alterations in membrane sialic acid content is reflected in the cell sensitivity to extracellular calcium, suggest an interaction between membrane sialic acid and the calcium channels involved in basophil histamine release.
ISSN:0065-4299
1420-908X
DOI:10.1007/BF02074657