New developments in the diagnosis of opportunistic fungal infection

This review considers recent developments in the diagnosis of aspergillosis, candidosis and cryptococcosis and discusses the prospects for routine application of a number of novel methods. The introduction of lysis-centrifugation and radiometric methods for blood culture has improved the diagnosis o...

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Bibliographic Details
Published in:European Journal of Clinical Microbiology 1986-08, Vol.5 (4), p.379-388
Main Authors: Hopwood, V, Warnock, D W
Format: Article
Language:English
Subjects:
Antigens, Fungal - analysis
Aspergillosis - diagnosis
Candidiasis - diagnosis
Chromatography, Gas
Cryptococcosis - diagnosis
Humans
Mycology - methods
Opportunistic Infections - diagnosis
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Summary:This review considers recent developments in the diagnosis of aspergillosis, candidosis and cryptococcosis and discusses the prospects for routine application of a number of novel methods. The introduction of lysis-centrifugation and radiometric methods for blood culture has improved the diagnosis of deep candidosis, but the value of these methods for the diagnosis of aspergillosis has not yet been determined. Recent developments in serological diagnosis have included the evaluation of newly discovered antigens of Candida albicans in an attempt to distinguish colonization from significant infection. Antigen detection, an established method for the diagnosis of cryptococcosis, has also been evaluated and appears promising for the diagnosis of aspergillosis and candidosis. Another promising approach has been the use of gas-liquid chromatography to detect fungal metabolites in serum and other host fluids.
ISSN:0722-2211
1435-4373
DOI:10.1007/BF02075691