Role of salivary and seric epidermal growth factor in pathogenesis of reflux esophagitis in chronic alcoholics and nondrinkers

Our objective was to investigate the putative role of epidermal growth factor (EGF) in esophagitis pathogenesis in both nondrinkers and chronic alcoholics. We studied the EGF serum level, the EGF salivary concentration, and the esophageal EGF receptor expression in different groups of patients with...

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Bibliographic Details
Published in:Digestive diseases and sciences 1996-08, Vol.41 (8), p.1595-1599
Main Authors: BENAMOUZIG, R, FERRIERE, F, GUETTIER, C, AMOUROUX, J, COSTE, T, RAUTUREAU, J
Format: Article
Language:English
Subjects:
Adult
Alcoholism - complications
Biological and medical sciences
Epidermal Growth Factor - metabolism
ErbB Receptors - metabolism
Esophagitis - metabolism
Esophagitis, Peptic - etiology
Esophagitis, Peptic - metabolism
Esophagus
Esophagus - metabolism
Esophagus - pathology
Esophagus - physiopathology
Female
Gastroenterology. Liver. Pancreas. Abdomen
Gastroesophageal Reflux - metabolism
Humans
Hydrogen-Ion Concentration
Immunohistochemistry
Male
Manometry
Medical sciences
Middle Aged
Monitoring, Physiologic
Other diseases. Semiology
Prospective Studies
Radioimmunoassay
Saliva - chemistry
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Summary:Our objective was to investigate the putative role of epidermal growth factor (EGF) in esophagitis pathogenesis in both nondrinkers and chronic alcoholics. We studied the EGF serum level, the EGF salivary concentration, and the esophageal EGF receptor expression in different groups of patients with esophagitis: nondrinkers with typical symptoms of gastroesophageal reflux (N = 12) and chronic alcoholics (N = 12), and in controls: chronic alcoholics without esophagitis (N = 16) and healthy nondrinkers (N = 12). All patients had an endoscopy with esophageal biopsies, 24-hr esophageal pH-metry, and esophageal manometry. EGF serum levels and EGF salivary concentrations were determined by radioimmunoassay. EGF receptor expression was determined by immunohistochemistry. Both the EGF serum level and the EGF salivary concentration remained constant, 328 +/- 21 pg/ml and 305 +/- 48 pg/ml, respectively, regardless of alcohol intake and the presence or absence of esophagitis. In addition, the presence of esophagitis did not affect the EGF receptor expression. These results suggest that seric and salivary EGF is not involved in the pathogenesis of reflux esophagitis in nondrinkers and in chronic alcoholics.
ISSN:0163-2116
1573-2568
DOI:10.1007/bf02087906