Correlations of the receptor content and ultrastructure of breast cancer cells

Receptor assay results were compared with the ultrastructure of 127 breast cancers (112 primary tumors, six recurrent lesions, nine metastases). Tumors were considered to be receptor positive if the receptor levels were greater than or equal to 15 fmol/mg of soluble tissue protein. Most breast cance...

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Bibliographic Details
Published in:Archives of Gynecology 1982-01, Vol.231 (3), p.177-184
Main Authors: Tulusan, A H, Hamann, M, Prestele, H, Ramming, I, von Maillot, K, Egger, H
Format: Article
Language:English
Subjects:
Breast Neoplasms - analysis
Breast Neoplasms - ultrastructure
Cell Differentiation
Female
Humans
Menopause
Microscopy, Electron
Neoplasm Metastasis
Neoplasm Recurrence, Local
Receptors, Estrogen - analysis
Receptors, Progesterone - analysis
Vacuoles - ultrastructure
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Summary:Receptor assay results were compared with the ultrastructure of 127 breast cancers (112 primary tumors, six recurrent lesions, nine metastases). Tumors were considered to be receptor positive if the receptor levels were greater than or equal to 15 fmol/mg of soluble tissue protein. Most breast cancer had heterogenous cells with different grades of ultrastructural differentiation. a prevalence of well-differentiated cancer cells and an abundance of intracytoplasmic vacuoles had a significant correlation with a positive estrogen receptor status. The correlation was better than between malignancy grades and receptor content. The type of breast cancer and the menopausal status bore no relation to receptor content. Progesterone receptors were found in well-differentiated tumors of low malignancy.
ISSN:0170-9925
1432-0711
DOI:10.1007/BF02110116