Different clinical presentations of a lupus anticoagulant in the same family

A young man who had suffered several episodes of deep-vein thrombosis of the legs since the age of 20 had a myocardial infarction at the age of 33, at which time both a prolonged partial thromboplastin time (PTT), compatible with a lupus anticoagulant (LA), and decreased fibrinolytic capacity (FC) w...

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Bibliographic Details
Published in:Klinische Wochenschrift 1991-05, Vol.69 (8), p.340-344
Main Authors: Jolidon, R M, Knecht, H, Humair, L, de Torrente, A
Format: Article
Language:English
Subjects:
Adult
Aged
Blood Coagulation Factors - analysis
Blood Coagulation Factors - genetics
Blood Coagulation Factors - immunology
Fibrinolysis - genetics
Humans
Lupus Coagulation Inhibitor
Lupus Erythematosus, Systemic - blood
Lupus Erythematosus, Systemic - genetics
Male
Myocardial Infarction - blood
Myocardial Infarction - genetics
Partial Thromboplastin Time
Risk Factors
Thrombophlebitis - blood
Thrombophlebitis - genetics
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Summary:A young man who had suffered several episodes of deep-vein thrombosis of the legs since the age of 20 had a myocardial infarction at the age of 33, at which time both a prolonged partial thromboplastin time (PTT), compatible with a lupus anticoagulant (LA), and decreased fibrinolytic capacity (FC) were found. His sister presented with deep-vein thrombosis of a leg and subsequent pulmonary embolism when she was 18 years old. She had a miscarriage three years later and developed a hemolytic-uremic syndrome at the age of 35. The PT and FC were normal. Laboratory investigations of the parents revealed positive antinuclear antibodies in the mother's serum but no anomaly in the father. This study suggests a familial tendency to develop autoimmune disorders associated with LA and thromboembolic complications related to decreased FC.
ISSN:0023-2173
1432-1440
DOI:10.1007/BF02115779