Liver injuries induced by herbal medicine, Syo-saiko-to (xiao-chai-hu-tang)

Four patients treated with the herbal medicine syo-saiko-to (xiao-chai-hu-tang) exhibited acute drug-induced liver injury. The latent period was one and a half to three months. All of the patients showed a rise in aminotransferases after readministration or challenge test. The liver histology reveal...

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Bibliographic Details
Published in:Digestive diseases and sciences 1995-08, Vol.40 (8), p.1845-1848
Main Authors: ITOH, S, MARUTANI, K, NISHIJIMA, T, MATSUO, S, ITABASHI, M
Format: Article
Language:English
Subjects:
Biological and medical sciences
Chemical and Drug Induced Liver Injury
Drug toxicity and drugs side effects treatment
Drugs, Chinese Herbal - adverse effects
Female
Humans
Liver - pathology
Liver Diseases - pathology
Medical sciences
Middle Aged
Pharmacology. Drug treatments
Toxicity: digestive system
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Summary:Four patients treated with the herbal medicine syo-saiko-to (xiao-chai-hu-tang) exhibited acute drug-induced liver injury. The latent period was one and a half to three months. All of the patients showed a rise in aminotransferases after readministration or challenge test. The liver histology revealed centrilobular confluent necrosis or spotty necrosis, microvesicular fatty change, acidophilic degeneration, and a granuloma. Cholestasis was seen in two patients. The results of the [13C]aminopyrine breath test, performed in one patient, were low before the challenge test and even lower after the challenge. These findings suggest that the herbal medicine syo-saiko-to may induce acute injury or the hepatocellular pattern with variable cholestasis.
ISSN:0163-2116
1573-2568
DOI:10.1007/BF02212712