Sperm stimulants can improve fertilization rates in male-factor cases undergoing IVF to the same extent as micromanipulation by partial zona dissection (PZD) or subzonal sperm insemination (SUZI): a randomized controlled study

Our purpose was to evaluate the efficacy of direct insemination (IVF), micromanipulation by partial zona dissection (PZD), and subzonal sperm insemination (SUZI) using sperm-treated with pentoxifylline (PF) +/- 2-deoxyadenosine (2DA). The overall fertilization rate achieved was similar for all three...

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Bibliographic Details
Published in:Journal of assisted reproduction and genetics 1995-05, Vol.12 (5), p.312-318
Main Authors: Edirisinghe, W R, Junk, S, Yovich, J M, Bootsma, B, Yovich, J L
Format: Article
Language:English
Subjects:
Deoxyadenosines - pharmacology
Female
Fertilization in Vitro - methods
Humans
Infertility, Male
Insemination, Artificial - methods
Male
Pentoxifylline - pharmacology
Phosphodiesterase Inhibitors - pharmacology
Pregnancy
Pregnancy Rate
Semen - physiology
Sperm Motility - drug effects
Sperm Motility - physiology
Spermatozoa - drug effects
Spermatozoa - physiology
Zona Pellucida - physiology
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Summary:Our purpose was to evaluate the efficacy of direct insemination (IVF), micromanipulation by partial zona dissection (PZD), and subzonal sperm insemination (SUZI) using sperm-treated with pentoxifylline (PF) +/- 2-deoxyadenosine (2DA). The overall fertilization rate achieved was similar for all three fertilization techniques (33.1, 30.2, and 26.9% for IVF, SUZI, and PZD, respectively). Patients who had reduced fertilization in previous IVF attempts showed improved fertilization with sperm stimulants, either PF alone or PF in combination with 2DA in standard IVF. In certain cases, SUZI or PZD gave significantly improved fertilization rates in comparison to IVF. Selective use of sperm stimulants in IVF can achieve fertilization for the majority of male-factor cases. However, PZD and SUZI techniques are useful, especially when sperm stimulants fail to achieve fertilization or achieve poor fertilization in direct insemination.
ISSN:1058-0468
1573-7330
DOI:10.1007/BF02213710