The action of ionizing radiation on DNA in the presence of quinacrine. I. UV absorption and fluorescence measurements

It is shown by UV absorption and absolute fluorescence spectroscopy of solutions containing both DNA and quinacrine that the components experience mutual radio-protection due to scavenging of water radicals. From measurements at different ionic strengths it is inferred that quinacrine bound to DNA i...

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Bibliographic Details
Published in:Radiation and environmental biophysics 1975-06, Vol.12 (1), p.5-12
Main Authors: Hissung, A, Dertinger, H, Heinrich, G
Format: Article
Language:English
Subjects:
Animals
Cattle
DNA - radiation effects
Dose-Response Relationship, Radiation
Gamma Rays
Quinacrine - radiation effects
Radiation Effects
Spectrometry, Fluorescence
Spectrophotometry, Ultraviolet
Thymus Gland
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Summary:It is shown by UV absorption and absolute fluorescence spectroscopy of solutions containing both DNA and quinacrine that the components experience mutual radio-protection due to scavenging of water radicals. From measurements at different ionic strengths it is inferred that quinacrine bound to DNA is more efficiently protected than the free compound. Furthermore, release of bound quinacrine from DNA is observed at higher doses.
ISSN:0301-634X
1432-2099
DOI:10.1007/BF02339804