Influence of proline and β-turn mimetics on the cyclization of penta- and hexapeptides

SummaryProline and Pro-derived peptidomimetics, such as meoxPro-Oic (4-methoxy-proline-octahydro indolic acid), and DBF (2-aminoethyl-6-dibenzofuran propionic acid) were introduced into thymopentin-derived penta-[SP5-] and hexa-[SP6-] peptides and penta-, hexa- and hepta-alanine. Surprisingly, we fo...

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Published in:International journal of peptide research and therapeutics 1998-05, Vol.5 (2-3), p.129-131
Main Authors: Klose, Jana, Ehrlich, Angelika, Bienert, Michael
Format: Article
Language:English
Subjects:
Alanine
Dibenzofuran
Peptidomimetics
Proline
Propionic acid
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description SummaryProline and Pro-derived peptidomimetics, such as meoxPro-Oic (4-methoxy-proline-octahydro indolic acid), and DBF (2-aminoethyl-6-dibenzofuran propionic acid) were introduced into thymopentin-derived penta-[SP5-] and hexa-[SP6-] peptides and penta-, hexa- and hepta-alanine. Surprisingly, we found that cyclomonomer formation in the investigated penta- and hexapeptides was drastically hindered by the presence of proline regardless of position.
doi_str_mv 10.1007/BF02443454
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source Springer Nature:Jisc Collections:Springer Nature Read and Publish 2023-2025: Springer Reading List
subjects Alanine
Dibenzofuran
Peptidomimetics
Proline
Propionic acid
title Influence of proline and β-turn mimetics on the cyclization of penta- and hexapeptides
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