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In vitro sensitivity test of stomach cancer tissues by the use of metal grid method
Ninety-nine specimens obtained from 53 patients with stomach cancer were cultured for about 3 days by means of the stainless steel grid method. In vitro effects of antitumor drugs on the cancer cells were evaluated autoradiographically or biochemically using a liquid scintillation counter to measure...
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| Published in: | Japanese journal of surgery 1979-12, Vol.9 (4), p.285-294 |
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| Main Authors: | , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c196t-514a4ae038de59b510b1ef7dcff2df75bc0562964071cd1252aea024fa8acee73 |
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| cites | cdi_FETCH-LOGICAL-c196t-514a4ae038de59b510b1ef7dcff2df75bc0562964071cd1252aea024fa8acee73 |
| container_end_page | 294 |
| container_issue | 4 |
| container_start_page | 285 |
| container_title | Japanese journal of surgery |
| container_volume | 9 |
| creator | Fujimoto, S Akao, T Itoh, B Kitsukawa, Y Takahashi, M Itoh, K |
| description | Ninety-nine specimens obtained from 53 patients with stomach cancer were cultured for about 3 days by means of the stainless steel grid method. In vitro effects of antitumor drugs on the cancer cells were evaluated autoradiographically or biochemically using a liquid scintillation counter to measure the uptake of 3H-thymidine. The radioactivity of the labeled tumor cells of both control fragments and fragments affected by drugs varied greatly among individual tumors. Therefore, the in vitro efficacy of antitumor drugs was represented as a comparison with that of control fragments. Positive correlation between in vitro tests and the clinical effects of antitumor drugs was observed in the specimens of 18 cases. |
| doi_str_mv | 10.1007/BF02468628 |
| format | article |
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| fulltext | fulltext |
| identifier | ISSN: 0047-1909 |
| ispartof | Japanese journal of surgery, 1979-12, Vol.9 (4), p.285-294 |
| issn | 0047-1909 1436-2813 |
| language | eng |
| recordid | cdi_crossref_primary_10_1007_BF02468628 |
| source | Springer Nature - Connect here FIRST to enable access |
| subjects | Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Cytarabine - pharmacology Drug Evaluation, Preclinical - methods Fluorouracil - pharmacology Humans In Vitro Techniques Methotrexate - pharmacology Mitomycins - pharmacology Stomach Neoplasms - drug therapy Stomach Neoplasms - metabolism Thymidine - metabolism |
| title | In vitro sensitivity test of stomach cancer tissues by the use of metal grid method |
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