Comparative study on the nuclear DNA content of leiomyoma, leiomyoblastoma and leiomyosarcoma of the stomach and small intestine

The nuclear DNA content of tumor cells in 5 leiomyomas, 4 leiomyoblastomas and 2 leiomyosarcomas of the stomach and 1 leiomyosarcoma of the small intestine was examined. From the viewpoint of nuclear DNA content, leiomyoblastoma was between leiomyoma and leiomyosarcoma. A definite difference in nucl...

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Bibliographic Details
Published in:Japanese journal of surgery 1981-11, Vol.11 (6), p.428-432
Main Authors: Kimura, O, Kaibara, N, Tamura, H, Nishidoi, H, Okamoto, T, Koga, S
Format: Article
Language:English
Subjects:
Adult
Aged
Diagnosis, Differential
DNA, Neoplasm - analysis
Female
Humans
Intestinal Neoplasms - analysis
Intestinal Neoplasms - diagnosis
Intestine, Small
Leiomyoma - analysis
Leiomyoma - diagnosis
Leiomyosarcoma - analysis
Leiomyosarcoma - diagnosis
Male
Middle Aged
Stomach Neoplasms - analysis
Stomach Neoplasms - diagnosis
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Summary:The nuclear DNA content of tumor cells in 5 leiomyomas, 4 leiomyoblastomas and 2 leiomyosarcomas of the stomach and 1 leiomyosarcoma of the small intestine was examined. From the viewpoint of nuclear DNA content, leiomyoblastoma was between leiomyoma and leiomyosarcoma. A definite difference in nuclear DNA content exists among leiomyoma, leiomyoblastoma and leiomyosarcoma, and percentage of nuclei with a DNA content of 3 times or 4 times over the basic chromosome content represented good indices for distinguishing between benign and malignant conditions. A diagnosis of leiomyocarcinoma may be more accurate when over 80% of the nuclei have DNA content values over 3 times of basic nuclear DNA content and when over 50% exhibit more than 4 times of basic content.
ISSN:0047-1909
1436-2813
DOI:10.1007/bf02469026