The correlation of epidermal growth factor with invasion and metastasis in human gastric cancer

We examined the localization of epidermal growth factor (EGF) in 185 specimens of primary human gastric cancer using the avidin-biotin peroxidase complex immunohistochemical method on formalin-fixed paraffin-embedded sections. Thirty-four per cent of the gastric cancer specimens were positive for EG...

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Bibliographic Details
Published in:Japanese journal of surgery 1990-05, Vol.20 (3), p.269-274
Main Authors: ONDA, M, TOKUNAGA, A, ASANO, G, NISHI, K, YOSHIYUKI, T, SHIMIZU, Y, KIYAMA, T, MIZUTANI, T, MATUKURA, N, TANAKA, N, YAMASHITA, K
Format: Article
Language:English
Subjects:
Biological and medical sciences
Epidermal Growth Factor - analysis
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Immunoenzyme Techniques
Lymphatic Metastasis
Medical sciences
Neoplasm Invasiveness
Stomach Neoplasms - metabolism
Stomach Neoplasms - mortality
Stomach Neoplasms - pathology
Survival Rate
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Summary:We examined the localization of epidermal growth factor (EGF) in 185 specimens of primary human gastric cancer using the avidin-biotin peroxidase complex immunohistochemical method on formalin-fixed paraffin-embedded sections. Thirty-four per cent of the gastric cancer specimens were positive for EGF, which was mainly located in the cytoplasm of the cancer cells and occasionally in the stromal cells, but was not detected in non-cancerous gastric epithelium. Moreover, the presence of EGF in gastric cancer was correlated with gastric wall invasion and lymph node metastasis. EGF was found more often in advanced cancers than in early ones (p less than 0.01), and also more often in cancers with lymph node metastasis than in those without (p less than 0.05). The five-year survival of patients with EGF-positive tumors was worse than that of patients with EGF-negative tumors (p less than 0.05). The presence of EGF in human gastric cancer may thus represent higher malignant potential.
ISSN:0047-1909
1436-2813
DOI:10.1007/BF02470660