Detection of androgen receptors in human esophageal cancer

The incidence of esophageal cancer is much higher in men than in women and the prognosis is generally worse in men than in women. This seems to depend on the difference in the hormonal environments of the patient. In this paper, androgen receptors (AR) were measured in 21 cases of human esophageal c...

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Bibliographic Details
Published in:Japanese journal of surgery 1989-03, Vol.19 (2), p.195-202
Main Authors: YAMASHITA, Y, HIRAI, T, MUKAIDA, H, KAWANO, K, TOGE, T, NIIMOTO, M, HATTORI, T
Format: Article
Language:English
Subjects:
Aged
Animals
Biological and medical sciences
Castration
Cell Division - drug effects
Cell Line
Esophageal Neoplasms - analysis
Esophageal Neoplasms - pathology
Esophagus
Estrogens - pharmacology
Female
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Male
Medical sciences
Mice
Mice, Nude
Middle Aged
Neoplasm Transplantation
Receptors, Androgen - analysis
Testosterone - pharmacology
Transplantation, Heterologous
Tumors
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Summary:The incidence of esophageal cancer is much higher in men than in women and the prognosis is generally worse in men than in women. This seems to depend on the difference in the hormonal environments of the patient. In this paper, androgen receptors (AR) were measured in 21 cases of human esophageal cancer. Of these, two cases of esophageal cancer xenografts implanted into nude mice were AR positive. In EH-1, an established cell line from human esophageal cancer, the number of binding sites was increased and tumor growth was enhanced by testosterone administration. On the other hand, the number of binding sites was decreased and tumor growth was suppressed by castration. The administration of estrogen, however, did not inhibit tumor growth.
ISSN:0047-1909
1436-2813
DOI:10.1007/BF02471585