Giant cavernous hemangioma of the liver and multiple primary malignant tumors in a patient with suspected familial inhibition of natural killer cell activity ―a case report

• Published in: Japanese journal of surgery 1989-03, Vol.19 (2), p.216-222
• Main Authors: TOMIYAMA, T, UCHIDA, K, AOKI, T, YOSHIDA, K, MUTO, T, SAITO, H, NEMOTO, K, INOUE, Z, MORITA, T, MIYAKOSHI, H, TAMURA, K
• Format: Article
• Language: English
• Subjects: Biological and medical sciences; Breast Neoplasms - genetics; Breast Neoplasms - immunology; Breast Neoplasms - pathology; Carcinoma - genetics; Carcinoma - immunology; Carcinoma - pathology; Female; Gastroenterology. Liver. Pancreas. Abdomen; Hemangioma, Cavernous - genetics; Hemangioma, Cavernous - immunology; Hemangioma, Cavernous - pathology; Humans; Killer Cells, Natural - immunology; Liver Neoplasms - genetics; Liver Neoplasms - immunology; Liver Neoplasms - pathology; Liver. Biliary tract. Portal circulation. Exocrine pancreas; Medical sciences; Middle Aged; Neoplasms, Multiple Primary - genetics; Neoplasms, Multiple Primary - immunology; Neoplasms, Multiple Primary - pathology; Ovarian Neoplasms - genetics; Ovarian Neoplasms - immunology; Ovarian Neoplasms - pathology; Tumors
• ISSN: 0047-1909; 1436-2813
• DOI: 10.1007/BF02471589

A woman was operated on for a nonepithelial malignant tumor of the left leg and subsequently, for an epithelial carcinoma of the right breast and a borderline malignant tumor of the right ovary. She also developed a giant cavernous hemangioma that caused disseminated intravascular coagulation syndrome, which necessitated a left trisegmentectomy of the liver. Her family history suggested a hereditary predisposition to diverse malignant neoplasms, and also to giant cavernous hemangioma of the liver. Immunological evaluation disclosed selective inhibition of natural killer cell activity. Hormonal and hereditary factors are discussed in relation to the development of multiple primary tumors and giant cavernous hemangioma of the liver.