Bronchial artery infusion of mitomycin C in carcinoma of the lung

Fifteen patients with bronchial carcinoma were treated with infusions of 10 mg Mitomycin C (MMC) in the bronchial artery feeding the tumor. The treatment was repeated three times with 2-3 weeks interval between treatments. Half of the patients then received radiation to the tumor area and mediastinu...

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Bibliographic Details
Published in:Cardiovascular and interventional radiology 1983-06, Vol.6 (2), p.86-96
Main Authors: Ekholm, S, Albrechtsson, U, Tylén, U
Format: Article
Language:English
Subjects:
Adenocarcinoma - drug therapy
Adenocarcinoma - mortality
Adenocarcinoma - radiotherapy
Aged
Bronchial Arteries - diagnostic imaging
Carcinoma, Bronchogenic - drug therapy
Carcinoma, Bronchogenic - mortality
Carcinoma, Bronchogenic - radiotherapy
Carcinoma, Squamous Cell - drug therapy
Carcinoma, Squamous Cell - mortality
Carcinoma, Squamous Cell - radiotherapy
Female
Humans
Infusions, Intra-Arterial - adverse effects
Lung Neoplasms - drug therapy
Lung Neoplasms - mortality
Lung Neoplasms - radiotherapy
Male
Middle Aged
Mitomycin
Mitomycins - administration & dosage
Mitomycins - adverse effects
Radiography
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Summary:Fifteen patients with bronchial carcinoma were treated with infusions of 10 mg Mitomycin C (MMC) in the bronchial artery feeding the tumor. The treatment was repeated three times with 2-3 weeks interval between treatments. Half of the patients then received radiation to the tumor area and mediastinum. All tumors decreased in size, complete remission occurred in two and partial remission in five patients. Survival time, however, was not prolonged and esophageal complications occurred in several patients.
ISSN:0174-1551
1432-086X
DOI:10.1007/BF02552778