B-cell response to a standardized breakfast in end-stage renal failure

Twelve uremic patients (U) on regular hemodialysis were submitted to a standardized test meal. In comparison with normal controls (C), U patients demonstrated a slight increase of HbA1 level and a definite elevation of fasting plasma C-peptide immunoreactivity. They showed glucose intolerance at 60...

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Bibliographic Details
Published in:Acta Diabetologica Latina 1985-01, Vol.22 (1), p.9-16
Main Authors: Daubresse, J C, Henrivaux, P, Dehout, F, Meunier, J C, Luyckx, A S, Lefebvre, P J
Format: Article
Language:English
Subjects:
Adult
Blood Glucose - metabolism
Female
Food, Formulated
Glucose Tolerance Test
Humans
Insulin - blood
Islets of Langerhans - physiopathology
Male
Middle Aged
Uremia - blood
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Summary:Twelve uremic patients (U) on regular hemodialysis were submitted to a standardized test meal. In comparison with normal controls (C), U patients demonstrated a slight increase of HbA1 level and a definite elevation of fasting plasma C-peptide immunoreactivity. They showed glucose intolerance at 60 and 120 min. This was associated with an inappropriate insulin response as evidenced by a significantly lower insulin/glucose index at 60 min. U patients were tested again during a hemodialysis session in order to reduce the 60-min glucose intolerance. Six patients (U1) were selected because they exhibited mean fasting and 60-min glucose values similar to those of the controls. In these conditions, the insulin response at 60 min was significantly decreased in comparison to basal conditions and this could not be accounted for by a concomitant decrease of plasma alpha-aminonitrogen values. It is concluded that, in uremic patients, glucose intolerance is associated with an inappropriately low B-cell response.
ISSN:0001-5563
1432-5233
DOI:10.1007/BF02591087