Role of red cell sorbitol as determinant of reduced erythrocyte filtrability in insulin-dependent diabetics

Erythrocyte deformability measured as filtration index is clearly diminished in diabetics, thus possibly contributing to diabetes-associated microvascular complications. Moreover, the erythrocyte sorbitol level in IDD is clearly higher than that of non-diabetics, suggesting an alteration in the poly...

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Bibliographic Details
Published in:Acta Diabetologica Latina 1982-10, Vol.19 (4), p.359-368
Main Authors: Carandente, O, Colombo, R, Girardi, A M, Margonato, A, Pozza, G
Format: Article
Language:English
Subjects:
2,3-Diphosphoglycerate
Adult
Aged
Blood Glucose - metabolism
Diabetes Mellitus, Type 1 - blood
Diphosphoglyceric Acids - blood
Erythrocytes - physiology
Female
Humans
Insulin - therapeutic use
Male
Middle Aged
Sorbitol - blood
Sugar Alcohols - blood
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Summary:Erythrocyte deformability measured as filtration index is clearly diminished in diabetics, thus possibly contributing to diabetes-associated microvascular complications. Moreover, the erythrocyte sorbitol level in IDD is clearly higher than that of non-diabetics, suggesting an alteration in the polyol pathway as possible determinant of diabetes-associated complications. Following this line of research, intracellular sorbitol as well as glucose, inositol, galactitol, mannitol and 2,3-diphosphoglycerate have been studied in 21 diabetics and in 14 controls matched for age and sex. In addition to confirming the high levels of intraerythrocytic glucose and sorbitol in diabetic subjects, statistically significant correlations have been demonstrated between sorbitol and filtration index, between plasma glucose, intracellular glucose level and glycosylated hemoglobin, suggesting a relationship between metabolic control and hemorheologic alterations in diabetes.
ISSN:0001-5563
1432-5233
DOI:10.1007/BF02629259