Self-tuning adaptive control of induced hypotension in humans : a comparison of isoflurane and sodium nitroprusside

Induced hypotension is commonly used during surgery to decrease arterial pressure. Sodium nitroprusside and isoflurane are well-known hypotensive agents. The use of self-tuning adaptive control of induced hypotension was assessed with the use of sodium nitroprusside and isoflurane as hypotensive age...

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Bibliographic Details
Published in:Journal of Clinical Monitoring 1990-07, Vol.6 (3), p.236-240
Main Authors: PRYS-ROBERTS, C, MILLARD, R. K
Format: Article
Language:English
Subjects:
Algorithms
Anesthesia
Anesthesia - methods
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Anesthesia: equipment, devices
Biological and medical sciences
Ferricyanides - pharmacology
Humans
Hypotension, Controlled - methods
Infusions, Intra-Arterial
Isoflurane - administration & dosage
Isoflurane - pharmacology
Medical sciences
Nitroprusside - administration & dosage
Nitroprusside - pharmacology
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Summary:Induced hypotension is commonly used during surgery to decrease arterial pressure. Sodium nitroprusside and isoflurane are well-known hypotensive agents. The use of self-tuning adaptive control of induced hypotension was assessed with the use of sodium nitroprusside and isoflurane as hypotensive agents. Nineteen surgical patients were studied during closed-loop control of hypotension induced with sodium nitroprusside. This group of patients was compared with 10 similar patients in whom infusions of sodium nitroprusside were controlled manually by an anesthesiologist. Although the results of the two studies varied, no conclusion could be drawn regarding the superiority of either manual or closed-loop control. When manual versus automatic control of isoflurane-induced hypotension was assessed in a similar fashion, the two methods of induction were found to be comparable.
ISSN:0748-1977
2214-7330
1573-2614
DOI:10.1007/BF02832153