A modified method for preparation of adriamycin carried by magnetic albumin microspheres

The targeting of antineoplastic agents to restricted anatomic sites and specific target cells have been challenged clinicians all the time in cancer chemotherapy, which resulted in recent efforts to focus the effects of existing antitumor agents and treatments on tumor cells and spare their effects...

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Bibliographic Details
Published in:Journal of Tongji Medical University 2001, Vol.21 (3), p.233-235
Main Authors: Ma, J, Chen, D, Tian, Y
Format: Article
Language:English
Subjects:
Antineoplastic Agents - administration & dosage
Doxorubicin - administration & dosage
Drug Administration Routes
Drug Carriers
Drug Delivery Systems
Humans
Immunotoxins
Magnetics
Microspheres
Particle Size
Pharmaceutical Preparations
Serum Albumin
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Summary:The targeting of antineoplastic agents to restricted anatomic sites and specific target cells have been challenged clinicians all the time in cancer chemotherapy, which resulted in recent efforts to focus the effects of existing antitumor agents and treatments on tumor cells and spare their effects on normal cells. The drug-carrier complex, adriamycin carried by magnetic albumin microspheres (ADM-MAM) was prepared by using our discovered new and modified method. The physical feature of the prepared drug-carrier microspheres was much better than by the traditional method in comparison. The successful preparation of the drug-carrier complex, ADM-MAM, is one of the key steps for our later further researches in the targeted chemotherapy.
ISSN:0257-716X
DOI:10.1007/bf02886439