Scanning electron microscopy of 7,12-dimethylbenz(a)-anthracene-induced mammary carcinoma in the female Sprague-Dawley rat

The surface morphology of normal mammary glands and mammary carcinomas was examined under the scanning electron microscope after digestion of connective tissue and the basal lamina with collagenase, hyaluronidase and hydrochloric acid (HCl). Two types of cells were clearly identified in the acini of...

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Bibliographic Details
Published in:Virchows Archiv. Abteilung B. Zellpathologie 1980-12, Vol.32 (2), p.105-108, Article 105
Main Authors: Yoshida, H, Yoshida, A, Fukunishi, R, Nagato, T, Uehara, Y
Format: Article
Language:English
Subjects:
9,10-Dimethyl-1,2-benzanthracene
Animals
Connective Tissue
Female
Mammary Glands, Animal - ultrastructure
Mammary Neoplasms, Experimental - chemically induced
Mammary Neoplasms, Experimental - ultrastructure
Microscopy, Electron, Scanning
Rats
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Summary:The surface morphology of normal mammary glands and mammary carcinomas was examined under the scanning electron microscope after digestion of connective tissue and the basal lamina with collagenase, hyaluronidase and hydrochloric acid (HCl). Two types of cells were clearly identified in the acini of normal glands; granular epithelial cells and stellate myoepithelial cells. Spindle-shaped myoepithelial cells lying longitudinally along the mammary ducts were also recognized. 7,12-dimethylbenz(a)anthracene-induced mammary carcinomas consisted of irregular masses of cells which had polypoid or columnar processes with rounded heads; the masses appeared to be composed of a single type of rhomboid cell. The tumors lacked the stellate or spindle-shaped myoepithelial cells found in normal acini and ducts.
ISSN:0340-6075
0042-6431
DOI:10.1007/BF02889019