Normal mitotic reactivity of fibroblasts and mesothelial cells in thrombocytopenic rat

Mitotic reactivity following 48/80-induced mast-cell secretion was studied in the mesentery of rats made thrombocytopenic, 7 days following a single injection of melphalan. In spite of a low platelet count (7% of normal), the mitogenic reaction of the mesenteric fibroblasts and mesothelial cells was...

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Bibliographic Details
Published in:Virchows Archiv. Abteilung B. Zellpathologie 1983-01, Vol.42 (2), p.185-192
Main Authors: Norrby, K, Rammer, L
Format: Article
Language:English
Subjects:
Animals
DNA - biosynthesis
Fibroblasts - pathology
Histamine Release
Male
Melphalan
Mesentery - pathology
Mitosis
Mitotic Index
Rats
Thrombocytopenia - chemically induced
Thrombocytopenia - pathology
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Summary:Mitotic reactivity following 48/80-induced mast-cell secretion was studied in the mesentery of rats made thrombocytopenic, 7 days following a single injection of melphalan. In spite of a low platelet count (7% of normal), the mitogenic reaction of the mesenteric fibroblasts and mesothelial cells was normal as judged by DNA-synthesis and mitotic index. The findings suggest that platelets and platelet-growth factors are not essential for the mast-cell-mediated mitogenic reaction of these two types of connective-tissue cells studied in vivo.
ISSN:0340-6075
0042-6431
DOI:10.1007/BF02890381