New cytotoxic benzopyrans from the leaves ofMallotus apelta

Two new benzopyrans 6-[1′-oxo-3′(R)-hydroxy-butyl]-5, 7-dimethoxy-2,2-dimethyl-2H-1-benzopyran (1) and 6-[1′-oxo-3′(R)-methoxy-butyl]-5,7-dimethoxy-2,2-dimethyl-2H-1-benzopyran (2) were isolated from the leaves ofMallotus apelta Muell.-Arg., (Euphorbiaceae). Their chemical structures were elucidated...

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Bibliographic Details
Published in:Archives of pharmacal research 2005-10, Vol.28 (10), p.1131-1134
Main Authors: Kiem, Phan Van, Dang, Nguyen Hai, Bao, Ha Viet, Huong, Hoang Thanh, Minh, Chau Van, Huong, Le Mai, Lee, Jung Joon, Kim, Young Ho
Format: Article
Language:English
Subjects:
benzopyrans
carcinoma
cells
chemical structure
cytotoxicity
Euphorbiaceae
hepatoma
human cell lines
humans
inhibitory concentration 50
leaves
nuclear magnetic resonance spectroscopy
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Summary:Two new benzopyrans 6-[1′-oxo-3′(R)-hydroxy-butyl]-5, 7-dimethoxy-2,2-dimethyl-2H-1-benzopyran (1) and 6-[1′-oxo-3′(R)-methoxy-butyl]-5,7-dimethoxy-2,2-dimethyl-2H-1-benzopyran (2) were isolated from the leaves ofMallotus apelta Muell.-Arg., (Euphorbiaceae). Their chemical structures were elucidated by spectroscopic analyses, especially by 1D- 2D-NMR and MS spectra. Compound1 was found to have strong cytotoxic effect against two human cancer cell lines as human hepatocellular carcinoma (Hep-2, IC₅₀: 0.49 μg/mL) and rhabdosarcoma (RD, IC₅₀: 0.54 μg/mL), while compound2 showed moderate activity against Hep-2 cell line (IC₅₀, 4.22μg/mL), byin vitro assay.
ISSN:0253-6269
1976-3786
DOI:10.1007/BF02972974