Glycosphingolipids in the cerebrospinal fluid of patients with multiple sclerosis

Glycosphingolipids in cerebrospinal fluid (CSF) of individual patients with multiple sclerosis (MS) were analyzed using a glycolipid-overlay technique. The ganglioside composition of CSF of non-MS patients was characterized by an abundance of polysialo species, including GT1b and GQ1b. This pattern...

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Bibliographic Details
Published in:Molecular and chemical neuropathology 1990-12, Vol.13 (3), p.205-216
Main Authors: MIYATANI, N, SAITO, M, ARIGA, T, YOSHINO, H, YU, R. K
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cholera Toxin - metabolism
Chromatography, Thin Layer
Gangliosides - cerebrospinal fluid
Glycolipids - cerebrospinal fluid
Glycosphingolipids - cerebrospinal fluid
Humans
Immunoglobulin G - biosynthesis
Immunoglobulin G - immunology
Medical sciences
Multiple Sclerosis - cerebrospinal fluid
Nervous System Diseases - cerebrospinal fluid
Neurology
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Summary:Glycosphingolipids in cerebrospinal fluid (CSF) of individual patients with multiple sclerosis (MS) were analyzed using a glycolipid-overlay technique. The ganglioside composition of CSF of non-MS patients was characterized by an abundance of polysialo species, including GT1b and GQ1b. This pattern is completely different from that of human white or gray matter, in which mono- and disialogangliosides predominate. Increased levels of GM1, either associated with or without increases of other gangliosides, such as GD1a, were observed in 16% of the patients with MS (6 of 37 cases: 1 of 15 progressive progressive stage, 4 of 16 progressive stationary stage, and 1 of 6 relapsing stage). The concentration of GD3 was increased in 23% (3 of 13 cases), whereas 1 of 13 cases (8%) showed a dramatic increase of sulfoglucuronyl paragloboside (SGPG) associated with a high level of GD3. These changes may reflect the cellular changes associated with the known pathological lesions in MS, which are characterized by demyelination, gliosis, and/or remyelination with oligodendrocytic proliferation.
ISSN:1044-7393
2168-8729
DOI:10.1007/BF03159923