Chronic mild stress induces variations in locomotive behavior and metabolic rates in high fat fed rats

Chronic mild stress (CMS) has been often associated to the pathogenesis of many diseases including obesity. Indeed, visceral obesity has been linked to the development of metabolic syndrome features and constitutes a serious risk factor for cardiovascular diseases and diabetes. In order to study pos...

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Bibliographic Details
Published in:Journal of physiology and biochemistry 2007-12, Vol.63 (4), p.337-346
Main Authors: García-Díaz, D F, Campion, J, Milagro, F I, Lomba, A, Marzo, F, Martínez, J A
Format: Article
Language:English
Subjects:
Animals
Body Composition
Body Weight
Dietary Fats - administration & dosage
Energy Metabolism - physiology
Male
Motor Activity - physiology
Obesity - etiology
Obesity - metabolism
Obesity - physiopathology
Rats
Rats, Wistar
Stress, Physiological - complications
Stress, Physiological - metabolism
Weight Gain
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Summary:Chronic mild stress (CMS) has been often associated to the pathogenesis of many diseases including obesity. Indeed, visceral obesity has been linked to the development of metabolic syndrome features and constitutes a serious risk factor for cardiovascular diseases and diabetes. In order to study possible mechanistic relationships between stress and the onset of obesity, we developed during 11 weeks a model of high-fat dietary intake (cafeteria diet) together with a CMS regimen in male Wistar rats. During the experimental period, basal metabolism by indirect calorimetry, rectal temperature, food intake, and locomotive markers were specifically analyzed. After 77 days, animals were sacrificed and body, adiposity and plasma biochemical profiles were also examined. As expected, cafeteria diet in unstressed animals induced a significative increase in body weight, adiposity, and insulin resistance markers. Locomotive variables, specifically distance, rearing and meander, were significantly increased by CMS on the first weeks of stress. Moreover, this model of CMS in Wistar rats increased significantly energy expenditure, and apparently interplayed with the dietary treatment on the muscle weight/fat weight ratio. In summary, this chronic stress model did not affected weight gain in control and high fat fed animals, but induced an interaction concerning the metabolic muscle/fat repartitioning.
ISSN:1138-7548
1877-8755
DOI:10.1007/BF03165765