Effect of melatonin on hyperlipidemic nephropathy under constant light exposure

Studies have shown anti-hyperlipidemic actions of melatonin, with pharmacological doses inducing changes in cholesterol levels. This study was designed to evaluate the effect of melatonin on adriamycin-induced (25mg/kg b.w., i.p.) hyperlipidemia under constant light exposure. Melatonin was injected...

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Bibliographic Details
Published in:Journal of physiology and biochemistry 2002-06, Vol.58 (2), p.109-114
Main Authors: Túnez, L, Muñoz, M C, Feijoo-López, A L, Valdvira, E, Bujalance-Arenas, L, Montilla, P
Format: Article
Language:English
Subjects:
Animals
Cholesterol - blood
Creatinine - blood
Doxorubicin - adverse effects
Hyperlipidemias - blood
Hyperlipidemias - chemically induced
Hyperlipidemias - metabolism
Kidney - drug effects
Kidney - metabolism
Kidney Diseases - blood
Kidney Diseases - chemically induced
Kidney Diseases - metabolism
Light
Lipoproteins, HDL - blood
Lipoproteins, HDL - classification
Lipoproteins, LDL - blood
Lipoproteins, LDL - classification
Male
Melatonin - metabolism
Melatonin - pharmacology
Proteinuria - chemically induced
Proteinuria - metabolism
Rats
Rats, Wistar
Triglycerides - blood
Urea - blood
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Summary:Studies have shown anti-hyperlipidemic actions of melatonin, with pharmacological doses inducing changes in cholesterol levels. This study was designed to evaluate the effect of melatonin on adriamycin-induced (25mg/kg b.w., i.p.) hyperlipidemia under constant light exposure. Melatonin was injected i.p. (1,000 microg/kg b.w./day). Triglycerides, total cholesterol, high-density lipoprotein cholesterol, light-density lipoprotein cholesterol, non-proteic nitrogen compounds (urea and creatinine levels), total protein in serum, proteins eliminated in the urine and melatonin levels in serum and kidney were determined. Results show a decrease in melatonin levels induced by both adriamycin and constant light. Likewise, adriamycin induced significant increases in triglycerides, total cholesterol and light-density lipoprotein cholesterol, and lowered high-density lipoprotein cholesterol levels. Constant light exposure also prompted an increase in LDL-c levels and a decrease in HDL-c values, and intensified the effects of adriamycin on these two lipoproteins. All changes induced by adriamycin and constant light were reverted toward normality by melatonin administration.
ISSN:1138-7548
1877-8755
DOI:10.1007/BF03179846