Effect of melatonin on hyperlipidemic nephropathy under constant light exposure

• Published in: Journal of physiology and biochemistry 2002-06, Vol.58 (2), p.109-114
• Main Authors: Túnez, L, Muñoz, M C, Feijoo-López, A L, Valdvira, E, Bujalance-Arenas, L, Montilla, P
• Format: Article
• Language: English
• Subjects: Animals; Cholesterol - blood; Creatinine - blood; Doxorubicin - adverse effects; Hyperlipidemias - blood; Hyperlipidemias - chemically induced; Hyperlipidemias - metabolism; Kidney - drug effects; Kidney - metabolism; Kidney Diseases - blood; Kidney Diseases - chemically induced; Kidney Diseases - metabolism; Light; Lipoproteins, HDL - blood; Lipoproteins, HDL - classification; Lipoproteins, LDL - blood; Lipoproteins, LDL - classification; Male; Melatonin - metabolism; Melatonin - pharmacology; Proteinuria - chemically induced; Proteinuria - metabolism; Rats; Rats, Wistar; Triglycerides - blood; Urea - blood
• ISSN: 1138-7548; 1877-8755
• DOI: 10.1007/BF03179846

Studies have shown anti-hyperlipidemic actions of melatonin, with pharmacological doses inducing changes in cholesterol levels. This study was designed to evaluate the effect of melatonin on adriamycin-induced (25mg/kg b.w., i.p.) hyperlipidemia under constant light exposure. Melatonin was injected i.p. (1,000 microg/kg b.w./day). Triglycerides, total cholesterol, high-density lipoprotein cholesterol, light-density lipoprotein cholesterol, non-proteic nitrogen compounds (urea and creatinine levels), total protein in serum, proteins eliminated in the urine and melatonin levels in serum and kidney were determined. Results show a decrease in melatonin levels induced by both adriamycin and constant light. Likewise, adriamycin induced significant increases in triglycerides, total cholesterol and light-density lipoprotein cholesterol, and lowered high-density lipoprotein cholesterol levels. Constant light exposure also prompted an increase in LDL-c levels and a decrease in HDL-c values, and intensified the effects of adriamycin on these two lipoproteins. All changes induced by adriamycin and constant light were reverted toward normality by melatonin administration.