Effect of cholic acid and its keto derivatives on the analgesic action of lidocaine and associated biochemical parameters in rats

This study examined the effect of the structure and concentration of cholic acid and its keto derivatives on the local analgesic action of lidocaine in rats, measured by an analgesimetric method. The increase in bile acid concentrations in the administered lidocaine solution increased the duration o...

Full description

Saved in:
Bibliographic Details
Published in:European journal of drug metabolism and pharmacokinetics 2007-04, Vol.32 (2), p.109-117
Main Authors: POSA, Mihalj, KEVRESAN, Slavko, MIKOV, Momir, CIRIN-NOVTA, Vera, KUHAJDA, Ksenija
Format: Article
Language:English
Subjects:
Analgesia
Anesthetics, Local - pharmacokinetics
Anesthetics, Local - pharmacology
Animals
Biological and medical sciences
Biological Transport
Cholic Acids - adverse effects
Cholic Acids - chemistry
Cholic Acids - pharmacology
Dose-Response Relationship, Drug
Drug Administration Schedule
Lidocaine - pharmacokinetics
Lidocaine - pharmacology
Male
Medical sciences
Micelles
Octanols - chemistry
Pain - drug therapy
Pain Measurement
Pharmacology. Drug treatments
Rats
Rats, Wistar
Solubility
Structure-Activity Relationship
Water - chemistry
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:This study examined the effect of the structure and concentration of cholic acid and its keto derivatives on the local analgesic action of lidocaine in rats, measured by an analgesimetric method. The increase in bile acid concentrations in the administered lidocaine solution increased the duration of local anesthesia. It was found that the introduction of keto groups into the cholic acid molecule yielded derivatives with lower promotory action, i.e. decreased the duration of local anesthesia. The biochemical parameters investigated indicated that the keto derivatives of cholic acid exhibited no toxicity compared to that of cholic acid itself.
ISSN:0378-7966
2107-0180
DOI:10.1007/BF03190999