Synthesis and biological study of novel bis-chalcones, bis-thiazines and bis-pyrimidines

A series of novel bis-chalcones 3 were prepared by the reaction of 5,5′-methylene-bis-salicylaldehyde 2 with various acetophenones, subsequent treatment of 3 with thiourea or guanidine resulted to the corresponding bis-thiazines or bispyrimidines in good yields. All the new compounds have been chara...

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Bibliographic Details
Published in:Journal of the Iranian Chemical Society 2008-06, Vol.5 (2), p.262-267
Main Authors: Nagaraj, A., Sanjeeva Reddy, C.
Format: Article
Language:English
Subjects:
Analytical Chemistry
Biochemistry
Chemistry
Chemistry and Materials Science
Inorganic Chemistry
Organic Chemistry
Physical Chemistry
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Summary:A series of novel bis-chalcones 3 were prepared by the reaction of 5,5′-methylene-bis-salicylaldehyde 2 with various acetophenones, subsequent treatment of 3 with thiourea or guanidine resulted to the corresponding bis-thiazines or bispyrimidines in good yields. All the new compounds have been characterized by IR, 1 H NMR, MS and elemental analysis. The antibacterial, antifungal and anti-inflammatory activities of the compounds have also been evaluated.
ISSN:1735-207X
1735-2428
DOI:10.1007/BF03246116