Endothelial function and endothelial nitric oxide synthase intron 4a/b polymorphism in primary hyperparathyroidism

Background and aim : Patients with symptomatic primary hyperparathyroidism (pHT) have increased cardiovascular morbidity and mortality. Endothelial nitric oxide synthase (eNOS) intron 4a/b polymorphism is associated with coronary artery disease and hypertension in various populations. Our aim is to...

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Bibliographic Details
Published in:Journal of endocrinological investigation 2009-07, Vol.32 (7), p.611-616
Main Authors: Ekmekci, A., Abaci, N., Ozbey, N. Colak, Agayev, A., Aksakal, N., Oflaz, H., Erginel-Unaltuna, N., Erbil, Y.
Format: Article
Language:English
Subjects:
Adult
Brachial Artery - anatomy & histology
Brachial Artery - physiology
Calcium - blood
Coronary Artery Disease - genetics
Coronary Artery Disease - physiopathology
Endocrinology
Endothelium, Vascular - enzymology
Endothelium, Vascular - physiology
Female
Genetic Predisposition to Disease
Genotype
Humans
Hyperparathyroidism, Primary - genetics
Hyperparathyroidism, Primary - physiopathology
Hyperparathyroidism, Primary - surgery
Introns
Male
Medicine
Medicine & Public Health
Metabolic Diseases
Middle Aged
Nitric Oxide Synthase Type III - genetics
Nitric Oxide Synthase Type III - metabolism
Original Articles
Parathyroid Hormone - blood
Parathyroidectomy
Polymorphism, Genetic
Vasodilation - genetics
Vasodilation - physiology
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Summary:Background and aim : Patients with symptomatic primary hyperparathyroidism (pHT) have increased cardiovascular morbidity and mortality. Endothelial nitric oxide synthase (eNOS) intron 4a/b polymorphism is associated with coronary artery disease and hypertension in various populations. Our aim is to evaluate endothelial function in patients with pHT during pre-operative hypercalcemic and post-operative normocalcemic periods and to determine whether intron 4a/b polymorphism of eNOS gene influences endothelial function. Subjects and Methods : Forty patients with pHT (age 48.48±11.64 yr) were examined pre-operatively and reexamined 5.8±1.9 months after parathyroidectomy. Forty-three healthy subjects (age 47.13±8.14 yr) were served as control group. Endothelial function was determined by flow-mediated dilation of brachial artery (FMD). eNOS4a/b polymorphism was detected by polymerase chain reaction. Results : FMD was significantly lower in patients pre-operatively compared with controls (8.48±1.78% vs 19.49±2.34%, p
ISSN:0391-4097
1720-8386
DOI:10.1007/BF03346518