Relationship of thyroid function with body mass index and insulin-resistance in euthyroid obese subjects

Background and aims : It is recognized that overt thyroid dysfunction is associated with weight changes, but the influence of a minor alteration of thyroid function remains unclear. This study aimed to further investigate the relationship between obesity and thyroid function and to examine the possi...

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Bibliographic Details
Published in:Journal of endocrinological investigation 2010-10, Vol.33 (9), p.640-643
Main Authors: Ambrosi, Bruno, Masserini, B., Iorio, L., Delnevo, A., Malavazos, A. E., Morricone, L., Sburlati, L. F., Orsi, E.
Format: Article
Language:English
Subjects:
Adult
Body Mass Index
Cohort Studies
Endocrinology
Female
Humans
Insulin Resistance - physiology
Male
Medicine
Medicine & Public Health
Metabolic Diseases
Middle Aged
Obesity - blood
Obesity - metabolism
Obesity - physiopathology
Overweight - blood
Overweight - metabolism
Overweight - physiopathology
Rapid Communication
Thyroid Function Tests
Thyroid Gland - physiopathology
Thyrotropin - blood
Thyroxine - blood
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Summary:Background and aims : It is recognized that overt thyroid dysfunction is associated with weight changes, but the influence of a minor alteration of thyroid function remains unclear. This study aimed to further investigate the relationship between obesity and thyroid function and to examine the possible role of insulin resistance on the hypothalamic-pituitary-thyroid axis. Methods and results : Serum TSH and free T 4 (FT 4 ) levels, anthropometric and metabolic parameters were evaluated in 581 obese patients. In all patients TSH values progressively increased according to the severity of obesity and were positively correlated with body mass index ( p =0.001, r=0.13) and waist circumference ( p =0.02, r=0.11). Patients with insulin resistance showed higher TSH (1.8±1.0 vs 1.6±0.9 μUI/l; p =0.03) and lower FT 4 levels (13.8±2.3 vs 15.0±2.2 pmol/l; p
ISSN:0391-4097
1720-8386
DOI:10.1007/BF03346663