Steroid myopathy: Some unresolved issues

Steroid myopathy is a non-inflammatory toxic myopathy that occurs as side effect of exogenous and endogenous glucocorticoid excess. The purpose of this review is to examine issues that limit our understanding of this myopathy with respect to nosology, etiopathogenesis, conditioning factors, and musc...

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Bibliographic Details
Published in:Journal of endocrinological investigation 2011-05, Vol.34 (5), p.370-375
Main Authors: Minetto, M. A., Lanfranco, F., Motta, G., Allasia, S., Arvat, E., D’Antona, G.
Format: Article
Language:English
Subjects:
Animals
Cushing Syndrome - complications
Cushing Syndrome - pathology
Cushing Syndrome - physiopathology
Cushing Syndrome - therapy
Endocrinology
Humans
Medicine
Medicine & Public Health
Metabolic Diseases
Muscle, Skeletal - drug effects
Muscle, Skeletal - pathology
Muscular Diseases - chemically induced
Muscular Diseases - epidemiology
Muscular Diseases - pathology
Muscular Diseases - physiopathology
Short Review
Steroids - adverse effects
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Summary:Steroid myopathy is a non-inflammatory toxic myopathy that occurs as side effect of exogenous and endogenous glucocorticoid excess. The purpose of this review is to examine issues that limit our understanding of this myopathy with respect to nosology, etiopathogenesis, conditioning factors, and muscle fiber selectivity. We suggest that if more data were available on these issues, the understanding of steroid myopathy would be enhanced substantially, thus allowing an early detection of its occurrence (before the appearance of clinical or laboratory signs) and a proper treatment of the patients.
ISSN:0391-4097
1720-8386
DOI:10.1007/BF03347462