Oncocytic mania: A review of oncocytic lesions throughout the body

Oncocytic lesions are characterized pathologically by an abundance of oncocytes, that is by enlarged, eosinophilic, and finely granular cells enriched in mitochondria. They can arise in numerous organs and tissues, often in endocrine glands, and have been associated with hyperplasia, autoimmunity, a...

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Bibliographic Details
Published in:Journal of endocrinological investigation 2011-05, Vol.34 (5), p.383-394
Main Authors: Guaraldi, F., Zang, G., Dackiw, A. P., Caturegli, P.
Format: Article
Language:English
Subjects:
Cell Transformation, Neoplastic
Endocrinology
Humans
Hyperplasia - pathology
Medicine
Medicine & Public Health
Metabolic Diseases
Mitochondria - pathology
Neoplasms - pathology
Oxyphil Cells - pathology
Review Article
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Summary:Oncocytic lesions are characterized pathologically by an abundance of oncocytes, that is by enlarged, eosinophilic, and finely granular cells enriched in mitochondria. They can arise in numerous organs and tissues, often in endocrine glands, and have been associated with hyperplasia, autoimmunity, and neoplasia. The causes and mechanisms that transform a normal cell into an oncocyte remain to be elucidated. Aim of this article is to review the most common oncocytic lesions, highlighting their key pathological features and clinical significance.
ISSN:0391-4097
1720-8386
DOI:10.1007/BF03347464