Effects of dehydroepiandrosterone (DHEA) supplementation on hormonal, metabolic and behavioral status in patients with hypoadrenalism

Oral DHEA administration to patients with hypoadrenalism, in addition to glucocorticoid and mineralcorticoid replacement, may improve both well-being and hormonal/metabolic parameters. Twenty patients (13 men, 7 women, 26-76 yr, 11 with Addison's disease, 9 with central hypoadrenalism) were rec...

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Published in:Journal of endocrinological investigation 2004-09, Vol.27 (8), p.736-741
Main Authors: Libè, R, Barbetta, L, Dall'Asta, C, Salvaggio, F, Gala, C, Beck-Peccoz, P, Ambrosi, B
Format: Article
Language:English
Subjects:
Addison Disease - drug therapy
Addison Disease - metabolism
Addison Disease - psychology
Adrenal Insufficiency - drug therapy
Adrenal Insufficiency - metabolism
Adrenal Insufficiency - psychology
Adult
Affect - drug effects
Aged
Androstenedione - blood
Behavior - physiology
Blood Glucose - metabolism
Body Composition - drug effects
Bone and Bones - drug effects
Bone and Bones - metabolism
Dehydroepiandrosterone - administration & dosage
Dehydroepiandrosterone - adverse effects
Dehydroepiandrosterone - therapeutic use
Dehydroepiandrosterone Sulfate - blood
Dietary Supplements
Double-Blind Method
Female
Hormones - blood
Humans
Lipids - blood
Male
Middle Aged
Sex Characteristics
Testosterone - blood
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Summary:Oral DHEA administration to patients with hypoadrenalism, in addition to glucocorticoid and mineralcorticoid replacement, may improve both well-being and hormonal/metabolic parameters. Twenty patients (13 men, 7 women, 26-76 yr, 11 with Addison's disease, 9 with central hypoadrenalism) were recruited in a placebo-controlled, randomized study. Hormone levels, carbohydrate and lipid parameters, bone metabolism, body composition and psychological parameters were evaluated at baseline and after treatment with DHEA 50 mg/day or placebo for 4 months. After 4 months of DHEA administration, serum DHEAS levels raised both in men (from 0.71+/-0.18 to 8.28+/-1.66 micropmol/l, p
ISSN:0391-4097
1720-8386
DOI:10.1007/BF03347515