A Cationic [60] Fullerene Derivative Reduces Invasion and Migration of HT-29 CRC Cells in Vitro at Dose Free of Significant Effects on Cell Survival

Nanomaterials with unique characteristics exhibit favorable therapeutic and diagnostic properties,implying their enormous potential as biomedical candidates. C60 has been used in gene- and drug-delivery, as imaging agents, and as photosensitizers in cancer therapy. In this study, the influences of a...

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Bibliographic Details
Published in:Nano-micro letters 2014-04, Vol.6 (2), p.163-168
Main Authors: Lucafò, Marianna, Pelillo, Chiara, Carini, Marco, Da Ros, Tatiana, Prato, Maurizio, Sava, Gianni
Format: Article
Language:English
Subjects:
Engineering
Nanoscale Science and Technology
Nanotechnology
Nanotechnology and Microengineering
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Summary:Nanomaterials with unique characteristics exhibit favorable therapeutic and diagnostic properties,implying their enormous potential as biomedical candidates. C60 has been used in gene- and drug-delivery, as imaging agents, and as photosensitizers in cancer therapy. In this study, the influences of a cationic functionalized fullerene on cellular behavior of human colorectal cancer cell line(HT-29) were investigated. Results indicated that HT-29 treated with the studied compound showed a lower sensitivity but a significant impairment in migration and invasion by interfering with the activities of matrix metalloproteinases(MMP-2 and9). The presence of fullerene also altered the capacity of adhesion-related proteins to perform their activity,thereby inducing dramatically adverse effects on the cell physiological functions such as cell adhesion. Thus,our study suggests that this compound is a new potential anti-metastatic effector and a therapeutic component for malignant colorectal cancer.
ISSN:2150-5551
2311-6706
2150-5551
DOI:10.1007/BF03353780